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pkn-1 protein kinase C [ Caenorhabditis elegans ]

Gene ID: 181244, updated on 2-Nov-2024

Summary

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Official Symbol
pkn-1
Official Full Name
protein kinase C
Primary source
WormBase:WBGene00009793
Locus tag
CELE_F46F6.2
See related
AllianceGenome:WB:WBGene00009793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Located in M band and striated muscle dense body. Is expressed in body wall musculature; intestine; nervous system; pharynx; and vulval muscle. Orthologous to several human genes including PKN3 (protein kinase N3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pkn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (10397242..10402576)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gustatory receptor family protein 3 Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans. Qadota H, et al. J Mol Biol, 2011 Mar 25. PMID 21277858, Free PMC Article
  2. Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components. Nahabedian JF, et al. Methods, 2012 Jan. PMID 22126736, Free PMC Article
  3. Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. Dhananjay S, et al. MicroPubl Biol, 2022. PMID 36530473, Free PMC Article
  4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle dense body HDA PubMed 
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C
NP_001257102.1
  • Confirmed by transcript evidence
NP_001359730.1
  • Confirmed by transcript evidence
NP_001360641.1
  • Confirmed by transcript evidence
NP_001360642.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10397242..10402576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373470.2 → NP_001360642.1  protein kinase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILM7
    Conserved Domains (5) summary
    cd11622
    Location:188 → 253
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:273 → 339
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:809 → 1134
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:344 → 410
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:527 → 589
    C2; C2 domain

  2. NM_001373472.2 → NP_001360641.1  protein kinase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IL76
    Conserved Domains (5) summary
    cd11622
    Location:69 → 134
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:154 → 220
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:690 → 1015
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:225 → 291
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:408 → 470
    C2; C2 domain

  3. NM_001373471.1 → NP_001359730.1  protein kinase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGE3
    Conserved Domains (5) summary
    cd11622
    Location:188 → 253
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:273 → 339
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:803 → 1128
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:344 → 410
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:527 → 589
    C2; C2 domain

  4. NM_001270173.4 → NP_001257102.1  protein kinase C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFX2
    Conserved Domains (6) summary
    cd11622
    Location:69 → 134
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:154 → 220
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:684 → 943
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:684 → 1009
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:225 → 291
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:408 → 470
    C2; C2 domain
Nucleotide Protein
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