mig-15 Serine/threonine-protein kinase mig-15 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mig-15
Official Full Name: Serine/threonine-protein kinase mig-15
Primary source: WormBase:WBGene00003247
Locus tag: CELE_ZC504.4
See related: AllianceGenome:WB:WBGene00003247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be active in cytoplasm. Is expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human TNIK (TRAF2 and NCK interacting kinase); MINK1 (misshapen like kinase 1); and MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mig-15 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 17

Sequence:: Chromosome: X; NC_003284.9 (10421653..10428657, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLX-1 suppresses local RAP-2 activity. Excessive ectopic synapse formation in mig-15 mutants causes a severe synaptic tiling defect. Conversely, overexpression of mig-15 strongly inhibited synapse formation, suggesting that mig-15 is a negative regulator of synapse formation.
Title: Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans.
Findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning.
Title: A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.
Data suggest that when MIG-38 is depleted, stimulation of a turning pathway is reduced, but MIG-15 could still couple with NCK-1 and promote distal tip cells (DTCs) motility.
Title: mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.
results support a model in which the MIG-15 kinase and the UNC-116-WVE-1 complex act on opposite sides of the growth cone to promote robust directional migration
Title: MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1.
MIG-15 NIK kinase affects Q cell polarization, maintenance of polarity, and migration, and acts independently of Wnt signaling.
Title: The MIG-15 NIK kinase acts cell-autonomously in neuroblast polarization and migration in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC504.4 (e-PCR)
- UniSTS:310382

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine/threonine-protein kinase mig-15

NP_001024971.1

Partially confirmed by transcript evidence

NP_001024972.1

Confirmed by transcript evidence

NP_001024973.1

Partially confirmed by transcript evidence

NP_001024974.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10421653..10428657 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029803.6 → NP_001024974.1 Serine/threonine-protein kinase mig-15 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024974.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23356

Conserved Domains (3) summary

smart00036
Location:749 → 1052

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:21 → 288

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:14 → 288

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_001029801.5 → NP_001024972.1 Serine/threonine-protein kinase mig-15 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024972.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23356

Conserved Domains (3) summary

smart00036
Location:759 → 1062

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:21 → 288

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:14 → 288

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_001029800.3 → NP_001024971.1 Serine/threonine-protein kinase mig-15 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024971.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23356

Conserved Domains (3) summary

smart00036
Location:764 → 1067

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:21 → 288

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:14 → 288

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
NM_001029802.5 → NP_001024973.1 Serine/threonine-protein kinase mig-15 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024973.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23356, Q8I4B5, Q8T8M3, Q95ZI7, Q9UAN7, Q9XYC3, Q9XYC4

Conserved Domains (3) summary

smart00036
Location:773 → 1076

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:21 → 288

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06608
Location:14 → 288

STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases