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haly-1 Histidine ammonia-lyase [ Caenorhabditis elegans ]

Gene ID: 181279, updated on 2-Nov-2024

Summary

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Official Symbol
haly-1
Official Full Name
Histidine ammonia-lyase
Primary source
WormBase:WBGene00009813
Locus tag
CELE_F47B10.2
See related
AllianceGenome:WB:WBGene00009813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histidine ammonia-lyase activity. Involved in L-histidine catabolic process. Predicted to be located in cytoplasm. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in histidinemia. Orthologous to human HAL (histidine ammonia-lyase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See haly-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (10893567..10896598, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Phage protein Neighboring gene Uncharacterized protein Neighboring gene ADH_N domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing. Bruinsma JJ, et al. Genetics, 2008 Jun. PMID 18505880, Free PMC Article
  2. Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. Murphy JT, et al. PLoS Genet, 2011 Mar. PMID 21455490, Free PMC Article
  3. SKN-1 regulates stress resistance downstream of amino catabolism pathways. Frankino PA, et al. iScience, 2022 Jul 15. PMID 35784796, Free PMC Article
  4. The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. Warnhoff K, et al. PLoS Genet, 2014 Oct. PMID 25330323, Free PMC Article
  5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables histidine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histidine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-histidine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-histidine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-histidine catabolic process to glutamate and formamide IEA
Inferred from Electronic Annotation
more info
  
involved_in L-histidine catabolic process to glutamate and formate IEA
Inferred from Electronic Annotation
more info
  
involved_in L-histidine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histidine ammonia-lyase
NP_509820.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10893567..10896598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077419.7 → NP_509820.1  Histidine ammonia-lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20502
    Conserved Domains (3) summary
    pfam12053
    Location:1 → 75
    DUF3534; Domain of unknown function (DUF3534)
    cl00013
    Location:127 → 632
    Lyase_I_like; Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions
    cl01247
    Location:87 → 164
    FliO; Flagellar biosynthesis protein, FliO
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20502.1

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