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acbp-3 Acyl-CoA-binding protein homolog 3 [ Caenorhabditis elegans ]

Gene ID: 181281, updated on 18-Sep-2024

Summary

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Official Symbol
acbp-3
Official Full Name
Acyl-CoA-binding protein homolog 3
Primary source
WormBase:WBGene00009818
Locus tag
CELE_F47B10.7
See related
AllianceGenome:WB:WBGene00009818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fatty-acyl-CoA binding activity and lipid binding activity. Involved in lipid storage. Is expressed in body wall musculature; hypodermis; and pharynx. Human ortholog(s) of this gene implicated in retinal dystrophy with leukodystrophy. Orthologous to human ACBD4 (acyl-CoA binding domain containing 4) and ACBD5 (acyl-CoA binding domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See acbp-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (10903272..10905088)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans. Elle IC, et al. Biochem J, 2011 Jul 15. PMID 21539519
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acyl-CoA-binding protein homolog 3
NP_509822.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10903272..10905088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077421.7 → NP_509822.2  Acyl-CoA-binding protein homolog 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509822.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20507
    Conserved Domains (1) summary
    cd00435
    Location:3 → 91
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20507.2

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