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dgn-1 Dystroglycan 1 [ Caenorhabditis elegans ]

Gene ID: 181283, updated on 2-Nov-2024

Summary

Official Symbol
dgn-1
Official Full Name
Dystroglycan 1
Primary source
WormBase:WBGene00000961
Locus tag
CELE_T21B6.1
See related
AllianceGenome:WB:WBGene00000961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable laminin binding activity. Involved in several processes, including axon extension involved in axon guidance; gonad morphogenesis; and inductive cell migration. Located in basal plasma membrane. Is expressed in several structures, including PVP; e2; gonad; gonadal primordium; and lumbar ganglion. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See dgn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (10920522..10928998, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene Sugar phosphate transporter domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables laminin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inductive cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of dystroglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of dystrophin-associated glycoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Dystroglycan 1
NP_001366742.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10920522..10928998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381093.2NP_001366742.1  Dystroglycan 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22629
    Conserved Domains (2) summary
    smart00736
    Location:244337
    CADG; Dystroglycan-type cadherin-like domains
    pfam05454
    Location:359584
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)