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pbo-4 Na(+)/H(+) exchanger protein 7 [ Caenorhabditis elegans ]

Gene ID: 181285, updated on 18-Sep-2024

Summary

Official Symbol
pbo-4
Official Full Name
Na(+)/H(+) exchanger protein 7
Primary source
WormBase:WBGene00003943
Locus tag
CELE_K09C8.1
See related
AllianceGenome:WB:WBGene00003943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Involved in several processes, including defecation; lipid transport involved in lipid storage; and positive regulation of intestinal lipid absorption. Located in basolateral plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See pbo-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (10954134..10958233)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Apple domain-containing protein Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Transmembrane protein Neighboring gene Zinc metalloproteinase nas-10

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in defecation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid transport involved in lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of intestinal lipid absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Na(+)/H(+) exchanger protein 7
NP_509830.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10954134..10958233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077429.9NP_509830.2  Na(+)/H(+) exchanger protein 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509830.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBK1
    Conserved Domains (1) summary
    pfam00999
    Location:115519
    Na_H_Exchanger; Sodium/hydrogen exchanger family