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egl-15 Myoblast growth factor receptor egl-15;receptor protein-tyrosine kinase [ Caenorhabditis elegans ]

Gene ID: 181291, updated on 2-Nov-2024

Summary

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Official Symbol
egl-15
Official Full Name
Myoblast growth factor receptor egl-15;receptor protein-tyrosine kinase
Primary source
WormBase:WBGene00001184
Locus tag
CELE_F58A3.2
See related
AllianceGenome:WB:WBGene00001184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase activity. Involved in several processes, including egg-laying behavior; fibroblast growth factor receptor signaling pathway; and muscle cell cellular homeostasis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in head neurons; hypodermis; intestine; male sex myoblast; and vulval muscle. Used to study bone disease. Human ortholog(s) of this gene implicated in several diseases, including bone development disease (multiple); breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to several human genes including FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egl-15 in Genome Data Viewer
Location:
chromosome: X
Exon count:
24
Sequence:
Chromosome: X; NC_003284.9 (11016400..11023421)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene RHDF1 Neighboring gene ncRNA Neighboring gene LIM domain-binding protein 1;LIM interaction domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Different isoforms of the C. elegans FGF receptor are required for attraction and repulsion of the migrating sex myoblasts. Lo TW, et al. Dev Biol, 2008 Jun 15. PMID 18455716, Free PMC Article
  2. The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor. Rodriguez Torres CS, et al. Dev Biol, 2024 Dec. PMID 39173814,
  3. clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Kokel M, et al. Genes Dev, 1998 May 15. PMID 9585503, Free PMC Article
  4. Protein chemical shift assignments of the unbound and RNA-bound forms of the alternative splicing factor SUP-12 from C. elegans. Amrane S, et al. Biomol NMR Assign, 2014 Apr. PMID 23334698
  5. A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Stern MJ, et al. Development, 1991 Nov. PMID 1821851

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor.
    Title: The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor.
  2. Egl-15 is required for neuromuscular junction regulation in response to stress. Egl-15 functions downstream of Skn-1 and sphk-1.
    Title: A Receptor Tyrosine Kinase Network Regulates Neuromuscular Function in Response to Oxidative Stress in Caenorhabditis elegans.
  3. Study identified the mechanism that maintains presynaptic distribution during postdevelopmental growth; the requirement of a SLC17 family transporter CIMA-1. CIMA-1 antagonizes a specific FGFR isoform, EGL-15(5A), in epidermal cells to modulate glial morphology, in turn modulating AIY synaptic distribution.[
    Title: Synapse location during growth depends on glia location.
  4. Intestinal tube formation in Caenorhabditis elegans requires egl-15 signaling
    Title: Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling.
  5. Results show that N-glycans negatively regulate EGL-15 FGFR activity in vivo supporting the notion that mutation of N-glycosylation sites in human FGFR may lead to inappropriate activation of the receptor.
    Title: N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo.
  6. EGL-15(5A) is predominantly expressed in the M lineage, which gives rise to the migrating sex myoblasts and their sex muscle descendants, while EGL-15(5B) is predominantly expressed in the hypodermis.
    Title: Different isoforms of the C. elegans FGF receptor are required for attraction and repulsion of the migrating sex myoblasts.
  7. EGL-15 and CLR-1 act in the hypodermis to regulate fluid homeostasis in worms
    Title: FGF signaling functions in the hypodermis to regulate fluid balance in C. elegans.
  8. Reporters for egl-15 exons 5A and 5B showed tissue-specific profiles, and we isolated mutants defective in the tissue specificity.
    Title: Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.
  9. report the identification of a novel EGL-15 receptor isoform that is generated by alternate splicing; present evidence that the two different forms of EGL-15 are responsible for its two distinct functions
    Title: Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell projection organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Myoblast growth factor receptor egl-15;receptor protein-tyrosine kinase
NP_001300355.1
  • Confirmed by transcript evidence
NP_001300356.1
  • Confirmed by transcript evidence
NP_001300364.1
  • Confirmed by transcript evidence
NP_001360406.1
  • Confirmed by transcript evidence
NP_001367004.1
  • Confirmed by transcript evidence
NP_001368579.1
  • Confirmed by transcript evidence
NP_001368580.1
  • Confirmed by transcript evidence
NP_001379182.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11016400..11023421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313427.4 → NP_001300356.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVM0
    Conserved Domains (5) summary
    cd04974
    Location:407 → 503
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    smart00410
    Location:401 → 502
    IG_like; Immunoglobulin like
    pfam07714
    Location:640 → 928
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:302 → 382
    Ig; Immunoglobulin domain
    cl21453
    Location:627 → 933
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001313426.3 → NP_001300355.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATB0
    Conserved Domains (5) summary
    cd04974
    Location:407 → 503
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    smart00410
    Location:401 → 502
    IG_like; Immunoglobulin like
    pfam07714
    Location:640 → 928
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:302 → 382
    Ig; Immunoglobulin domain
    cl21453
    Location:627 → 933
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001373496.2 → NP_001360406.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYK2
    Conserved Domains (4) summary
    smart00409
    Location:41 → 126
    IG; Immunoglobulin
    cd04974
    Location:407 → 503
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cl11960
    Location:302 → 382
    Ig; Immunoglobulin domain
    cl21453
    Location:627 → 933
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001313435.5 → NP_001300364.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYL0
    Conserved Domains (6) summary
    cd00096
    Location:51 → 123
    Ig; Immunoglobulin domain
    cd04974
    Location:355 → 451
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    smart00410
    Location:349 → 450
    IG_like; Immunoglobulin like
    pfam07714
    Location:588 → 876
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:250 → 330
    Ig; Immunoglobulin domain
    cl21453
    Location:575 → 881
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001392839.1 → NP_001379182.1  Myoblast growth factor receptor egl-15 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10656, Q7JL68, Q7YZM7, Q7YZM8, Q7YZN0, Q7YZN1, Q7Z025, Q8MQ14, Q93804, Q95QE0, Q95QE1
    Conserved Domains (5) summary
    smart00410
    Location:41 → 126
    IG_like; Immunoglobulin like
    cd00096
    Location:309 → 317
    Ig; Ig strand B [structural motif]
    cd04974
    Location:392 → 501
    IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:302 → 382
    Ig; Immunoglobulin domain
    cl21453
    Location:627 → 933
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001381095.1 → NP_001368580.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASS4
    Conserved Domains (5) summary
    smart00410
    Location:41 → 126
    IG_like; Immunoglobulin like
    cd00096
    Location:257 → 265
    Ig; Ig strand B [structural motif]
    cd04974
    Location:340 → 449
    IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:250 → 330
    Ig; Immunoglobulin domain
    cl21453
    Location:575 → 881
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001381096.1 → NP_001368579.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATB5
    Conserved Domains (5) summary
    smart00410
    Location:41 → 126
    IG_like; Immunoglobulin like
    cd00096
    Location:257 → 265
    Ig; Ig strand B [structural motif]
    cd04974
    Location:340 → 449
    IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:250 → 330
    Ig; Immunoglobulin domain
    cl21453
    Location:575 → 881
    PKc_like; Protein Kinases, catalytic domain

  8. NM_001381098.1 → NP_001367004.1  Myoblast growth factor receptor egl-15 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (5) summary
    smart00410
    Location:41 → 126
    IG_like; Immunoglobulin like
    cd00096
    Location:257 → 265
    Ig; Ig strand B [structural motif]
    cd04974
    Location:340 → 449
    IgI_3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:250 → 330
    Ig; Immunoglobulin domain
    cl21453
    Location:575 → 881
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10656.1

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