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Ints6 integrator complex subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 18130, updated on 2-Nov-2024

Summary

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Official Symbol
Ints6provided by MGI
Official Full Name
integrator complex subunit 6provided by MGI
Primary source
MGI:MGI:1202397
See related
Ensembl:ENSMUSG00000035161 AllianceGenome:MGI:1202397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HDB; DICE1; Ddx26; Notch2l; 2900075H24Rik
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of integrator complex. Is expressed in neural retina and neural retinal epithelium. Orthologous to human INTS6 (integrator complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 6.7), placenta adult (RPKM 5.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ints6 in Genome Data Viewer
Location:
14 D1; 14 33.23 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (62913774..62998617, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62676325..62761163, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23816 Neighboring gene serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 Neighboring gene predicted gene, 25162 Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36903 Neighboring gene RIKEN cDNA 4931440J10 gene Neighboring gene STARR-positive B cell enhancer ABC_E756 Neighboring gene predicted gene, 35678 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7323 Neighboring gene predicted gene, 26536 Neighboring gene microRNA 8098 Neighboring gene WD repeat and FYVE domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DBI-1, a novel gene related to the notch family, modulates mitogenic response to insulin-like growth factor 1. Hoff HB 3rd, et al. Exp Cell Res, 1998 Feb 1. PMID 9473344
  2. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Lachke SA, et al. Science, 2011 Mar 25. PMID 21436445, Free PMC Article
  3. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Vervoort SJ, et al. Cell, 2021 Jun 10. PMID 34004147, Free PMC Article
  4. A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Thut CJ, et al. Dev Biol, 2001 Mar 1. PMID 11180952
  5. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Transgenic (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator complex subunit 6
Names
DBI-1
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26
int6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008715.2 → NP_032741.2  integrator complex subunit 6

    See identical proteins and their annotated locations for NP_032741.2

    Status: PROVISIONAL

    Source sequence(s)
    BC059263
    Consensus CDS
    CCDS27191.1
    UniProtKB/Swiss-Prot
    Q3TA02, Q61204, Q6PCM2, Q6PDL7, Q8BQZ7
    Related
    ENSMUSP00000086788.5, ENSMUST00000053959.7
    Conserved Domains (2) summary
    pfam15300
    Location:806 → 864
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    pfam13519
    Location:4 → 131
    VWA_2; von Willebrand factor type A domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    62913774..62998617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315909.3 → XP_017171398.1  integrator complex subunit 6 isoform X3

    UniProtKB/Swiss-Prot
    Q6PCM2
    Conserved Domains (2) summary
    pfam15300
    Location:797 → 855
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    pfam13519
    Location:4 → 131
    VWA_2; von Willebrand factor type A domain

  2. XM_006518680.5 → XP_006518743.1  integrator complex subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_006518743.1

    Conserved Domains (2) summary
    pfam15300
    Location:807 → 865
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    pfam13519
    Location:4 → 131
    VWA_2; von Willebrand factor type A domain

  3. XM_017315908.3 → XP_017171397.1  integrator complex subunit 6 isoform X1

    Conserved Domains (2) summary
    pfam15300
    Location:807 → 865
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    pfam13519
    Location:4 → 131
    VWA_2; von Willebrand factor type A domain

  4. XM_011244985.4 → XP_011243287.1  integrator complex subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_011243287.1

    Conserved Domains (2) summary
    pfam15300
    Location:807 → 865
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    pfam13519
    Location:4 → 131
    VWA_2; von Willebrand factor type A domain

  5. XM_011244986.4 → XP_011243288.1  integrator complex subunit 6 isoform X2

    See identical proteins and their annotated locations for XP_011243288.1

    UniProtKB/Swiss-Prot
    Q3TA02, Q61204, Q6PCM2, Q6PDL7, Q8BQZ7
    Related
    ENSMUSP00000152954.2, ENSMUST00000223585.2
    Conserved Domains (2) summary
    pfam15300
    Location:806 → 864
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    pfam13519
    Location:4 → 131
    VWA_2; von Willebrand factor type A domain

  6. XM_006518682.5 → XP_006518745.1  integrator complex subunit 6 isoform X3

    See identical proteins and their annotated locations for XP_006518745.1

    UniProtKB/Swiss-Prot
    Q6PCM2
    Conserved Domains (2) summary
    pfam15300
    Location:797 → 855
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    pfam13519
    Location:4 → 131
    VWA_2; von Willebrand factor type A domain

  7. XM_036158504.1 → XP_036014397.1  integrator complex subunit 6 isoform X5

    Conserved Domains (1) summary
    pfam15300
    Location:618 → 677
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  8. XM_006518683.4 → XP_006518746.1  integrator complex subunit 6 isoform X4

    Conserved Domains (1) summary
    pfam15300
    Location:629 → 687
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCM2.1 GenPept UniProtKB/Swiss-Prot:Q6PCM2

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