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hst-2 Heparan sulfate 2-O-sulfotransferase hst-2 [ Caenorhabditis elegans ]

Gene ID: 181309, updated on 2-Nov-2024

Summary

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Official Symbol
hst-2
Official Full Name
Heparan sulfate 2-O-sulfotransferase hst-2
Primary source
WormBase:WBGene00002029
Locus tag
CELE_C34F6.4
See related
AllianceGenome:WB:WBGene00002029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heparan sulfate 2-O-sulfotransferase activity. Involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; regulation of axon guidance; and regulation of cell migration. Predicted to be located in Golgi apparatus. Is expressed in several structures, including P6.pa; P6.paa; P6.pap; hermaphrodite distal tip cell; and somatic nervous system. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hst-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (11204103..11207155, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene MARVEL domain-containing protein Neighboring gene NR LBD domain-containing protein Neighboring gene Transmembrane protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans. Kinnunen T, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15671174, Free PMC Article
  2. Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans. Dierker T, et al. Sci Rep, 2016 Oct 5. PMID 27703236, Free PMC Article
  3. Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans. Turnbull J, et al. Biochem Soc Trans, 2003 Apr. PMID 12653634
  4. Genetic analysis of the heparan modification network in Caenorhabditis elegans. Townley RA, et al. J Biol Chem, 2011 May 13. PMID 21454666, Free PMC Article
  5. Direct visualization of specifically modified extracellular glycans in living animals. Attreed M, et al. Nat Methods, 2012 Apr 1. PMID 22466794, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulfotransferase activity in C. elegans is critical for normal heparan sulfate functions in controlling cell migration.
    Title: Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heparan sulfate 2-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparan sulfate 2-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparan sulfate 2-O-sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Heparan sulfate 2-O-sulfotransferase hst-2
NP_509871.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11204103..11207155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077470.6 → NP_509871.2  Heparan sulfate 2-O-sulfotransferase hst-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509871.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17645
    Conserved Domains (1) summary
    cl22970
    Location:42 → 293
    Sulfotransfer_2; Sulfotransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17645.2

Gene LinkOut

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