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F38B2.4 Adenylate kinase isoenzyme 1 [ Caenorhabditis elegans ]

Gene ID: 181317, updated on 2-Nov-2024

Summary

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Official Symbol
F38B2.4
Official Full Name
Adenylate kinase isoenzyme 1
Primary source
WormBase:WBGene00009531
Locus tag
CELE_F38B2.4
See related
AllianceGenome:WB:WBGene00009531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable adenylate kinase activity. Predicted to be involved in nucleotide metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F38B2.4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (11286578..11287717, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene CUB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article
  2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in AMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Adenylate kinase isoenzyme 1
NP_001257141.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11286578..11287717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270212.3 → NP_001257141.1  Adenylate kinase isoenzyme 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257141.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20140
    Conserved Domains (2) summary
    TIGR01360
    Location:18 → 206
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:22 → 195
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RNA

  1. NR_072112.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20140.1

Gene LinkOut

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