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prx-12 Peroxisome assembly protein 12 [ Caenorhabditis elegans ]

Gene ID: 181331, updated on 2-Nov-2024

Summary

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Official Symbol
prx-12
Official Full Name
Peroxisome assembly protein 12
Primary source
WormBase:WBGene00004197
Locus tag
CELE_F08B12.2
See related
AllianceGenome:WB:WBGene00004197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-protein transferase activity. Involved in nematode larval development and peroxisome organization. Predicted to be located in membrane and peroxisome. Predicted to be part of peroxisomal importomer complex. Predicted to be active in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 3A and peroxisome biogenesis disorder 3B. Orthologous to human PEX12 (peroxisomal biogenesis factor 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prx-12 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (11393294..11394619)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene PRoMiNin (5-transmembrane domain glycoprotein) homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ion_trans_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders. Petriv OI, et al. Physiol Genomics, 2002 Aug 14. PMID 12181365
  2. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
  3. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
  4. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
  5. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, et al. Curr Biol, 2007 Feb 6. PMID 17276923

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into peroxisome matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into peroxisome matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of peroxisomal importomer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Peroxisome assembly protein 12
NP_001309444.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11393294..11394619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322631.3 → NP_001309444.1  Peroxisome assembly protein 12 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19189
    Conserved Domains (2) summary
    smart00184
    Location:292 → 329
    RING; Ring finger
    pfam04757
    Location:31 → 256
    Pex2_Pex12; Pex2 / Pex12 amino terminal region
Nucleotide Protein
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