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slo-2 Ion_trans_2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181332, updated on 2-Nov-2024

Summary

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Official Symbol
slo-2
Official Full Name
Ion_trans_2 domain-containing protein
Primary source
WormBase:WBGene00004831
Locus tag
CELE_F08B12.3
See related
AllianceGenome:WB:WBGene00004831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calcium-activated potassium channel activity and outward rectifier potassium channel activity. Involved in positive regulation of neurotransmitter secretion and potassium ion transport. Located in axon. Is expressed in body wall musculature; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See slo-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
27
Sequence:
Chromosome: X; NC_003284.9 (11394605..11405931, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PRoMiNin (5-transmembrane domain glycoprotein) homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Peroxisome assembly protein 12 Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Eukaryotic translation initiation factor 2-alpha kinase pek-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of K(+) currents using an in situ patch clamp technique in body wall muscle cells from Caenorhabditis elegans. Jospin M, et al. J Physiol, 2002 Oct 15. PMID 12381812, Free PMC Article
  2. Dissection of K+ currents in Caenorhabditis elegans muscle cells by genetics and RNA interference. Santi CM, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14612577, Free PMC Article
  3. Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca(2+)-activated K(+) channels. Lim HH, et al. Gene, 1999 Nov 15. PMID 10564810
  4. The sodium-activated potassium channel is encoded by a member of the Slo gene family. Yuan A, et al. Neuron, 2003 Mar 6. PMID 12628167
  5. SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. Wojtovich AP, et al. PLoS One, 2011. PMID 22145034, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mutations of HRPU-2, a worm homolog of mammalian hnRNP U, result in dysfunction of a Slo2 potassium channel, which is critical to neuronal function
    Title: HRPU-2, a Homolog of Mammalian hnRNP U, Regulates Synaptic Transmission by Controlling the Expression of SLO-2 Potassium Channel in Caenorhabditis elegans.
  2. Decreased Slo-2 expression reduced behavioral impairment during ethanol withdrawal.
    Title: Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in Caenorhabditis elegans.
  3. SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry.
    Title: SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.
  4. SLO-2 potassium channel is an important regulator of neurotransmitter release.
    Title: SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans.
  5. The C. elegans SLO-2 channels possess unique biophysical and functional properties.
    Title: SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.
  6. in vivo SLO-2 channels were active only when intracellular Ca2+ and Cl- were raised above normal physiological conditions
    Title: Dissection of K+ currents in Caenorhabditis elegans muscle cells by genetics and RNA interference.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-activated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables intracellular sodium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables outward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ion_trans_2 domain-containing protein
NP_001024527.1
  • Confirmed by transcript evidence
NP_001024528.1
  • Confirmed by transcript evidence
NP_001024529.1
  • Confirmed by transcript evidence
NP_001129924.1
  • Confirmed by transcript evidence
NP_001257144.1
  • Confirmed by transcript evidence
NP_001257145.1
  • Partially confirmed by transcript evidence
NP_001257146.1
  • Partially confirmed by transcript evidence
NP_001257147.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11394605..11405931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029357.5 → NP_001024528.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024528.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDJ1
    Conserved Domains (3) summary
    pfam00520
    Location:117 → 289
    Ion_trans; Ion transport protein
    pfam03493
    Location:451 → 546
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:219 → 291
    Ion_trans_2; Ion channel

  2. NM_001029356.4 → NP_001024527.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024527.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECD1
    Conserved Domains (3) summary
    pfam00520
    Location:117 → 289
    Ion_trans; Ion transport protein
    pfam03493
    Location:451 → 546
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:219 → 291
    Ion_trans_2; Ion channel

  3. NM_001136452.4 → NP_001129924.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129924.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2MZB8
    Conserved Domains (3) summary
    pfam00520
    Location:114 → 286
    Ion_trans; Ion transport protein
    pfam03493
    Location:448 → 543
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:216 → 288
    Ion_trans_2; Ion channel

  4. NM_001029358.5 → NP_001024529.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024529.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q565B7
    Conserved Domains (3) summary
    pfam00520
    Location:96 → 268
    Ion_trans; Ion transport protein
    pfam03493
    Location:430 → 525
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:198 → 270
    Ion_trans_2; Ion channel

  5. NM_001270215.3 → NP_001257144.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257144.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2R6
    Conserved Domains (3) summary
    pfam00520
    Location:150 → 322
    Ion_trans; Ion transport protein
    pfam03493
    Location:484 → 579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:252 → 324
    Ion_trans_2; Ion channel

  6. NM_001270216.3 → NP_001257145.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257145.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2R3
    Conserved Domains (3) summary
    pfam00520
    Location:135 → 307
    Ion_trans; Ion transport protein
    pfam03493
    Location:469 → 564
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:237 → 309
    Ion_trans_2; Ion channel

  7. NM_001270217.4 → NP_001257146.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257146.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2R4
    Conserved Domains (3) summary
    pfam00520
    Location:153 → 320
    Ion_trans; Ion transport protein
    pfam03493
    Location:487 → 582
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:255 → 327
    Ion_trans_2; Ion channel

  8. NM_001270218.3 → NP_001257147.1  Ion_trans_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257147.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2R7
    Conserved Domains (3) summary
    pfam00520
    Location:140 → 312
    Ion_trans; Ion transport protein
    pfam03493
    Location:474 → 569
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 314
    Ion_trans_2; Ion channel
Nucleotide Protein
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