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hum-4 Myosin motor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181335, updated on 2-Nov-2024

Summary

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Official Symbol
hum-4
Official Full Name
Myosin motor domain-containing protein
Primary source
WormBase:WBGene00002037
Locus tag
CELE_F46C3.3
See related
AllianceGenome:WB:WBGene00002037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin binding activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be located in cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; actin-based cell projection; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA) and MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hum-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
42
Sequence:
Chromosome: X; NC_003284.9 (11420465..11433588, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A family of unconventional myosins from the nematode Caenorhabditis elegans. Baker JP, et al. J Mol Biol, 1997 Oct 3. PMID 9325109
  2. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article
  3. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
  4. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
  5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Myosin motor domain-containing protein
NP_001257158.1
  • Confirmed by transcript evidence
NP_001257159.1
  • Confirmed by transcript evidence
NP_001257161.1
  • Partially confirmed by transcript evidence
NP_001294791.1
  • Confirmed by transcript evidence
NP_001294792.1
  • Confirmed by transcript evidence
NP_001359540.1
  • Confirmed by transcript evidence
NP_001360186.1
  • Confirmed by transcript evidence
NP_001379502.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11420465..11433588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373507.3 → NP_001359540.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20456
    Conserved Domains (7) summary
    smart00015
    Location:680 → 701
    IQ; Calmodulin-binding motif
    smart00139
    Location:2100 → 2255
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:2262 → 2475
    B41; Band 4.1 homologues
    PRK10263
    Location:1162 → 1357
    PRK10263; DNA translocase FtsK; Provisional
    cd14874
    Location:13 → 643
    MYSc_Myo12; class XXXIII myosin, motor domain
    cl17036
    Location:1974 → 2030
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:2489 → 2563
    PH-like; Pleckstrin homology-like domain

  2. NM_001392845.1 → NP_001379502.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6KRJ0
    Conserved Domains (4) summary
    smart00139
    Location:486 → 641
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:648 → 861
    B41; Band 4.1 homologues
    cl17036
    Location:360 → 416
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:875 → 949
    PH-like; Pleckstrin homology-like domain

  3. NM_001270232.4 → NP_001257161.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6VQ62
    Conserved Domains (5) summary
    smart00139
    Location:523 → 678
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:685 → 898
    B41; Band 4.1 homologues
    pfam00373
    Location:776 → 898
    FERM_M; FERM central domain
    cl17036
    Location:397 → 453
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:912 → 986
    PH-like; Pleckstrin homology-like domain

  4. NM_001373506.3 → NP_001360186.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6F568
    Conserved Domains (7) summary
    smart00015
    Location:680 → 701
    IQ; Calmodulin-binding motif
    smart00139
    Location:2063 → 2218
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:2225 → 2438
    B41; Band 4.1 homologues
    PRK10263
    Location:1162 → 1357
    PRK10263; DNA translocase FtsK; Provisional
    cd14874
    Location:13 → 643
    MYSc_Myo12; class XXXIII myosin, motor domain
    cl17036
    Location:1937 → 1993
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:2452 → 2526
    PH-like; Pleckstrin homology-like domain

  5. NM_001307862.4 → NP_001294791.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294791.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FD20
    Conserved Domains (7) summary
    smart00139
    Location:861 → 1016
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1023 → 1236
    B41; Band 4.1 homologues
    pfam00373
    Location:1114 → 1236
    FERM_M; FERM central domain
    pfam15752
    Location:1 → 91
    DUF4688; Domain of unknown function (DUF4688)
    pfam17069
    Location:197 → 380
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:735 → 791
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:1250 → 1324
    PH-like; Pleckstrin homology-like domain

  6. NM_001270229.4 → NP_001257158.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257158.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT13
    Conserved Domains (6) summary
    smart00139
    Location:898 → 1053
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1060 → 1273
    B41; Band 4.1 homologues
    pfam00373
    Location:1151 → 1273
    FERM_M; FERM central domain
    pfam17069
    Location:197 → 380
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:772 → 828
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:1287 → 1361
    PH-like; Pleckstrin homology-like domain

  7. NM_001307863.4 → NP_001294792.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6EZR2
    Conserved Domains (7) summary
    smart00139
    Location:772 → 927
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:934 → 1147
    B41; Band 4.1 homologues
    pfam00373
    Location:1025 → 1147
    FERM_M; FERM central domain
    pfam15512
    Location:237 → 341
    CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
    pfam17069
    Location:108 → 291
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:646 → 702
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:1161 → 1235
    PH-like; Pleckstrin homology-like domain

  8. NM_001270230.4 → NP_001257159.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT14
    Conserved Domains (6) summary
    smart00139
    Location:809 → 964
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:971 → 1184
    B41; Band 4.1 homologues
    pfam00373
    Location:1062 → 1184
    FERM_M; FERM central domain
    pfam17069
    Location:108 → 291
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:683 → 739
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:1198 → 1272
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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