lin-14 Protein lin-14 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-14
Official Full Name: Protein lin-14
Primary source: WormBase:WBGene00003003
Locus tag: CELE_T25C12.1
See related: AllianceGenome:WB:WBGene00003003
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Is expressed in several structures, including P3.p hermaphrodite; neurons; oocyte; seam cell; and somatic nervous system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-14 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (11465560..11485871)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The heterochronic LIN-14 protein is a BEN domain transcription factor.
Title: The heterochronic LIN-14 protein is a BEN domain transcription factor.
These results identify a crucial role for LIN-14 in preventing axonal degeneration and in maintaining correct interaction between an axon and its surrounding tissue.
Title: The Heterochronic Gene lin-14 Controls Axonal Degeneration in C. elegans Neurons.
results point to the importance of translational inhibition in silencing of lin-14 by the lin-4 miRNA
Title: Dual regulation of the lin-14 target mRNA by the lin-4 miRNA.
By counting transcripts in individual worms, we show that pulsatile expression of the microRNA lin-4 maintains the temporal gradient of its target lin-14 by dampening its expression oscillations.
Title: Dampening of expression oscillations by synchronous regulation of a microRNA and its target.
LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning.
Title: LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning.
These experiments outline a function for LIN-14 in coordinating the temporal progression of development, which is separable from its role in regulating stage-specific events during C. elegans postembryonic development.
Title: The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system.
Study demonstrates that nutrient deprivation results in loss of lin-14 mRNA, but not protein, repression.
Title: Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans.
lin-4 and lin-14 regulate life span in the adult
Title: A developmental timing microRNA and its target regulate life span in C. elegans.
lin-14 encodes a novel class of transcription factor.
Title: The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25C12.1 (e-PCR)
- UniSTS:318902

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of development, heterochronic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode larval development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info