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selt-1.1 Thioredoxin reductase-like selenoprotein T homolog selt-1.1 [ Caenorhabditis elegans ]

Gene ID: 181343, updated on 2-Nov-2024

Summary

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Official Symbol
selt-1.1
Official Full Name
Thioredoxin reductase-like selenoprotein T homolog selt-1.1
Primary source
WormBase:WBGene00007955
Locus tag
CELE_C35C5.3
See related
AllianceGenome:WB:WBGene00007955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including P5.paaa; amphid neurons; body wall musculature; epithelial cell; and pharyngeal cell. Orthologous to human SELENOT (selenoprotein T). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See selt-1.1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (11545047..11546495, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene N-acetylated-alpha-linked acidic dipeptidase 2 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans. Romanelli-Cedrez L, et al. Free Radic Biol Med, 2017 Jul. PMID 28347729
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans
    Title: Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Thioredoxin reductase-like selenoprotein T homolog selt-1.1
NP_509929.2
  • Confirmed by transcript evidence
NP_509930.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11545047..11546495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077529.5 → NP_509930.2  Thioredoxin reductase-like selenoprotein T homolog selt-1.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509930.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3N5
    Conserved Domains (1) summary
    cl01407
    Location:84 → 222
    Rdx; Rdx family

  2. NM_077528.4 → NP_509929.2  Thioredoxin reductase-like selenoprotein T homolog selt-1.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509929.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93327, Q9U3N5
    Conserved Domains (1) summary
    cl01407
    Location:87 → 225
    Rdx; Rdx family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U3N5.2

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