mig-2 Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mig-2
Official Full Name: Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein
Primary source: WormBase:WBGene00003239
Locus tag: CELE_C35C5.4
See related: AllianceGenome:WB:WBGene00003239
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and engulfment of apoptotic cell. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Is expressed in several structures, including distal tip cell; linker cell; neurons; somatic gonad precursor; and vulval cell. Used to study epilepsy. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mig-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (11548608..11550692)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-73, the C. elegans ortholog of Trio, is a guanine nucleotide exchange factor (GEF) upstream of both CED-10 and MIG-2 that is suppressed by CMRL1
Title: Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans.
active form of RhoG/MIG-2 directly binds to Anillin and recruits it to the leading edge of Q neuroblasts
Title: Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton.
Genetic interaction data with Rac GTPase activators and effectors suggest that CACN-1 acts specifically to inhibit the mig-2/Rac pathway, and in parallel to ced-10/Rac, to control distal tip cells.
Title: CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.
results suggest that MAX-2 and MIG-2 play a crucial role in mediating the heavy metal stress response regulated by the KGB-1 pathway.
Title: The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.
MIG-2 plays an important role in defining the distinct migratory behavior of Q neuroblasts in C. elegans.
Title: Molecular signatures of cell migration in C. elegans Q neuroblasts.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C35C5.4 (e-PCR)
- UniSTS:317951

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemorepulsion of axon	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	HEP more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of microtubule polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in netrin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in organelle organization	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell leading edge	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein

NP_001300334.1

Confirmed by transcript evidence

NP_509931.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11548608..11550692

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077530.5 → NP_509931.1 Ras-related C3 botulinum toxin substrate 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509931.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBV3

Conserved Domains (2) summary

smart00174
Location:10 → 183

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd00157
Location:8 → 178

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
NM_001313405.4 → NP_001300334.1 Signal recognition particle protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AYI6

Conserved Domains (1) summary

cl21455
Location:1 → 66

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases