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mes-1 Protein mes-1 [ Caenorhabditis elegans ]

Gene ID: 181362, updated on 2-Nov-2024

Summary

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Official Symbol
mes-1
Official Full Name
Protein mes-1
Primary source
WormBase:WBGene00003219
Locus tag
CELE_F54F7.5
See related
AllianceGenome:WB:WBGene00003219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; establishment of mitotic spindle localization; and left/right axis specification. Located in plasma membrane. Is expressed in E; Psub2; Psub3; Psub4; and germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mes-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (11857478..11862373)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene MX region of TRA-2 Related Neighboring gene Ovule protein Neighboring gene Elongin-C Neighboring gene Conserved plasma membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans. Strome S, et al. Development, 1995 Sep. PMID 7555722
  2. Differences in maternal supply and early development of closely related nematode species. Laugsch M, et al. Int J Dev Biol, 2004 Sep. PMID 15470638
  3. Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisation. Hird SN, et al. Development, 1996 Apr. PMID 8620857
  4. Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans. Kreher J, et al. Genetics, 2018 Nov. PMID 30217796, Free PMC Article
  5. Positioning of polarity formation by extracellular signaling during asymmetric cell division. Seirin Lee S. J Theor Biol, 2016 Jul 7. PMID 27086039

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the roles in epigenetic inheritance of MES-4 and MET-1
    Title: Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans.
  2. mes-1 encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germ line and has a role in P. aeruginosa-induced neurodegeneration
    Title: Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.
  3. Data show that the asymmetry of GPR-1/2 (which act with GOA-1 and GPA-16) localization depends on PAR-3 and its downstream intermediate LET-99, as well as on the MES-1/SRC-1 signaling pathway.
    Title: LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric protein localization involved in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in developmental process involved in reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in left/right axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein mes-1
NP_741906.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11857478..11862373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171780.8 → NP_741906.1  Protein mes-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741906.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBL2
    Conserved Domains (1) summary
    cl21453
    Location:815 → 954
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EBL2.1

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