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set-6 Histone-lysine N-methyltransferase set-6 [ Caenorhabditis elegans ]

Gene ID: 181371, updated on 2-Nov-2024

Summary

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Official Symbol
set-6
Official Full Name
Histone-lysine N-methyltransferase set-6
Primary source
WormBase:WBGene00008206
Locus tag
CELE_C49F5.2
See related
AllianceGenome:WB:WBGene00008206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables histone H3K9 dimethyltransferase activity and histone H3K9 trimethyltransferase activity. Involved in epigenetic regulation of gene expression. Located in chromatin. Is expressed in embryonic cell; gonad; muscle cell; nervous system; and sperm. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See set-6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (11970077..11974679, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative S-adenosylmethionine synthase 1 Neighboring gene Nuclear hormone receptor family member nhr-167 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two conserved epigenetic regulators prevent healthy ageing. Yuan J, et al. Nature, 2020 Mar. PMID 32103178
  2. Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator. Leight ER, et al. Genetics, 2015 Mar. PMID 25567989, Free PMC Article
  3. Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells. Cai L, et al. Biochem Biophys Res Commun, 2014 May 2. PMID 24727455, Free PMC Article
  4. Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans. Shao Y, et al. Sci Total Environ, 2024 Sep 10. PMID 38851356
  5. The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans. Weng C, et al. Genes Dev, 2019 Jan 1. PMID 30567997, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H3 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 dimethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 trimethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9me2 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone-lysine N-methyltransferase set-6
NP_510003.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11970077..11974679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077602.6 → NP_510003.2  Histone-lysine N-methyltransferase set-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510003.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17679
    Conserved Domains (1) summary
    smart00317
    Location:455 → 603
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17679.2

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