U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rgs-2 RGS domain-containing protein;Regulator of G-protein signaling rgs-2 [ Caenorhabditis elegans ]

Gene ID: 181414, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
rgs-2
Official Full Name
RGS domain-containing protein;Regulator of G-protein signaling rgs-2
Primary source
WormBase:WBGene00004345
Locus tag
CELE_F16H9.1
See related
AllianceGenome:WB:WBGene00004345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Is expressed in head neurons; pharyngeal muscle cell; tail neurons; uterine muscle; and ventral cord neurons. Orthologous to several human genes including RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rgs-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (12712653..12728391)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Nuclear Hormone Receptor family Neighboring gene Nuclear Hormone Receptor family Neighboring gene Nuclear hormone receptor family member nhr-27 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene P-GlycoProtein related

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Dusonchet J, et al. Hum Mol Genet, 2014 Sep 15. PMID 24794857, Free PMC Article
  2. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Kang C, et al. Genes Dev, 2007 Sep 1. PMID 17785524, Free PMC Article
  3. Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep. Huang H, et al. G3 (Bethesda), 2017 Sep 7. PMID 28743807, Free PMC Article
  4. The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity. Krzyzanowski MC, et al. PLoS Genet, 2013. PMID 23874221, Free PMC Article
  5. G-protein signaling: satisfying the basic necessities of life. Wilkie TM. Curr Biol, 2000 Nov 30. PMID 11114530

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
RGS domain-containing protein;Regulator of G-protein signaling rgs-2
NP_001123134.1
  • Confirmed by transcript evidence
NP_001257199.1
  • Confirmed by transcript evidence
NP_001379248.1
  • Confirmed by transcript evidence
NP_510124.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12712653..12728391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392863.1 → NP_001379248.1  RGS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFV0
    Conserved Domains (1) summary
    cl02565
    Location:52 → 169
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_077723.6 → NP_510124.2  Regulator of G-protein signaling rgs-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510124.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49808
    Conserved Domains (1) summary
    cl02565
    Location:40 → 157
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. NM_001129662.4 → NP_001123134.1  RGS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123134.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECA3
    Conserved Domains (1) summary
    cl02565
    Location:33 → 150
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. NM_001270270.5 → NP_001257199.1  RGS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFC5
    Conserved Domains (1) summary
    cl02565
    Location:38 → 155
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49808.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.