unc-9 Innexin;Innexin unc-9 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: unc-9
Official Full Name: Innexin;Innexin unc-9
Primary source: WormBase:WBGene00006749
Locus tag: CELE_R12H7.1
See related: AllianceGenome:WB:WBGene00006749
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin filament binding activity and gap junction channel activity. Involved in monoatomic ion transmembrane transport and positive regulation of locomotion. Located in gap junction. Is expressed in several structures, including anchor cell; muscle cell; neurons; phasmid sheath cell; and somatic nervous system. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

UNC-7S and UNC-9 are widely expressed and contribute to a large number of the gap junctions identified in the locomotory.nervous system.
Title: Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system.
UNC-9 is localized perisynaptically throughout development and is required in presynaptic neurons to regulate active zone differentiation.
Title: Caenorhabditis elegans innexins regulate active zone differentiation.
unc-9 has a role in neuromuscular transmission
Title: Low conductance gap junctions mediate specific electrical coupling in body-wall muscle cells of Caenorhabditis elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	IDA Inferred from Direct Assay more info	PubMed
enables gap junction channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables gap junction channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in gap junction	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info