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cdk-4 Cyclin-dependent kinase 4 homolog [ Caenorhabditis elegans ]

Gene ID: 181472, updated on 2-Nov-2024

Summary

Official Symbol
cdk-4
Official Full Name
Cyclin-dependent kinase 4 homolog
Primary source
WormBase:WBGene00000406
Locus tag
CELE_F18H3.5
See related
AllianceGenome:WB:WBGene00000406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including male gonad development; positive regulation of brood size; and positive regulation of cell cycle process. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in gonad; intestine; neurons; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including familial melanoma; high grade glioma (multiple); pancreatic carcinoma (multiple); primary autosomal recessive microcephaly 12; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See cdk-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (13515856..13518911, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DM13 domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene SPRY domain-containing protein 7 Neighboring gene Polyadenylate-binding protein Neighboring gene ncRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle G1/S phase transition TAS
Traceable Author Statement
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of brood size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sex determination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Cyclin-dependent kinase 4 homolog
NP_510256.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13515856..13518911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077855.8NP_510256.1  Cyclin-dependent kinase 4 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510256.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTR1
    Conserved Domains (2) summary
    smart00220
    Location:38324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:38324
    PKc_like; Protein Kinases, catalytic domain