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F18H3.4 Lebercilin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181474, updated on 2-Nov-2024

Summary

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Official Symbol
F18H3.4
Official Full Name
Lebercilin domain-containing protein
Primary source
WormBase:WBGene00008940
Locus tag
CELE_F18H3.4
See related
AllianceGenome:WB:WBGene00008940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Involved in IRE1-mediated unfolded protein response and innate immune response. Predicted to be part of ribonucleoprotein complex. Predicted to be active in endoplasmic reticulum and nuclear outer membrane-endoplasmic reticulum membrane network. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F18H3.4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (13529088..13531941)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SPRY domain-containing protein 7 Neighboring gene Polyadenylate-binding protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AcetylCholine Receptor Neighboring gene ncRNA Neighboring gene Histidine-rich glycoprotein-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in innate immune response HEP PubMed 
involved_in intracellular mRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear outer membrane-endoplasmic reticulum membrane network IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Lebercilin domain-containing protein
NP_510261.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13529088..13531941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077860.7 → NP_510261.1  Lebercilin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510261.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19580
    Conserved Domains (1) summary
    TIGR02169
    Location:23 → 227
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein
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