unc-84 Nuclear migration and anchoring protein unc-84 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-84
Official Full Name: Nuclear migration and anchoring protein unc-84
Primary source: WormBase:WBGene00006816
Locus tag: CELE_F54B11.3
See related: AllianceGenome:WB:WBGene00006816
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables lamin binding activity. Involved in several processes, including egg-laying behavior; nuclear migration along microtubule; and vulval development. Located in nuclear inner membrane. Is expressed widely. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Orthologous to several human genes including SUN2 (Sad1 and UNC84 domain containing 2) and SUN3 (Sad1 and UNC84 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-84 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (13584775..13589821)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUN-KASH bridges are only required to maintain nuclear envelope spacing in cells subjected to increased mechanical forces.
Title: The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture.
targeting UNC-84 requires an initial step that actively transports UNC-84 from the peripheral endoplasmic reticulum to the nuclear envelope
Title: Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane.
UNC-84 and UNC-83, the KASH and SUN domain proteins, bridge the nuclear envelope, connecting the nuclear lamina to cytoskeletal components.
Title: UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54B11.3 (e-PCR)
- UniSTS:311763

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables lamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in localization	IEA Inferred from Electronic Annotation more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	TAS Traceable Author Statement more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of meiotic nuclear membrane microtubule tethering complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear migration and anchoring protein unc-84

NP_001024707.1

Confirmed by transcript evidence

NP_001366990.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13584775..13589821

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029536.6 → NP_001024707.1 Nuclear migration and anchoring protein unc-84 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024707.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20745, Q9U475, Q9U476

Conserved Domains (1) summary

pfam07738
Location:972 → 1108

Sad1_UNC; Sad1 / UNC-like C-terminal
NM_001381134.2 → NP_001366990.1 Nuclear migration and anchoring protein unc-84 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PHA01351
Location:645 → 769

PHA01351; putative minor structural protein