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twk-20 Two pore potassium channel protein sup-9 [ Caenorhabditis elegans ]

Gene ID: 181485, updated on 2-Nov-2024

Summary

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Official Symbol
twk-20
Official Full Name
Two pore potassium channel protein sup-9
Primary source
WormBase:WBGene00006673
Locus tag
CELE_C40C9.1
See related
AllianceGenome:WB:WBGene00006673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in muscle cell and neurons. Human ortholog(s) of this gene implicated in Birk-Barel syndrome and primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3) and KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See twk-20 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (13639877..13642359)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AcetylCholine Receptor Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-throughput behavioral analysis in C. elegans. Swierczek NA, et al. Nat Methods, 2011 Jun 5. PMID 21642964, Free PMC Article
  2. Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms. Buckingham SD, et al. Trends Pharmacol Sci, 2005 Jul. PMID 15939489
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Two pore potassium channel protein sup-9
NP_510284.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13639877..13642359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077883.2 → NP_510284.1  Two pore potassium channel protein sup-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECW6
    Conserved Domains (1) summary
    pfam07885
    Location:175 → 250
    Ion_trans_2; Ion channel
Nucleotide Protein
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