U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gck-4 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181488, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
gck-4
Official Full Name
Protein kinase domain-containing protein
Primary source
WormBase:WBGene00007287
Locus tag
CELE_C04A11.3
See related
AllianceGenome:WB:WBGene00007287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Is expressed in excretory cell; head; intestine; pharynx; and tail. Orthologous to human SLK (STE20 like kinase) and STK10 (serine/threonine kinase 10). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See gck-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (13677192..13682340)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Disintegrin and metalloproteinase domain-containing protein adm-2 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics. Knox J, et al. Sci Rep, 2021 Apr 28. PMID 33911106, Free PMC Article
  2. Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle. Qadota H, et al. Mol Biol Cell, 2018 Aug 15. PMID 29949401, Free PMC Article
  3. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
  4. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
  5. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Fridolfsson HN, et al. Dev Biol, 2010 Feb 15. PMID 20005871, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Protein kinase domain-containing protein
NP_001360654.1
  • Confirmed by transcript evidence
NP_510290.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13677192..13682340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077889.5 → NP_510290.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510290.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17566
    Conserved Domains (2) summary
    cd06611
    Location:28 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    pfam12474
    Location:862 → 995
    PKK; Polo kinase kinase

  2. NM_001373560.5 → NP_001360654.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKG6
    Conserved Domains (2) summary
    cd06611
    Location:28 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    pfam12474
    Location:862 → 995
    PKK; Polo kinase kinase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools