adm-2 Disintegrin and metalloproteinase domain-containing protein adm-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: adm-2
Official Full Name: Disintegrin and metalloproteinase domain-containing protein adm-2
Primary source: WormBase:WBGene00000074
Locus tag: CELE_C04A11.4
See related: AllianceGenome:WB:WBGene00000074
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in endosome membrane; lysosomal membrane; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cone-rod dystrophy 9; lung disease (multiple); osteoarthritis; and rhinitis. Orthologous to several human genes including ADAM19 (ADAM metallopeptidase domain 19) and ADAM33 (ADAM metallopeptidase domain 33). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See adm-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (13687955..13695801)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04A11.4 (e-PCR)
- UniSTS:308918

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Disintegrin and metalloproteinase domain-containing protein adm-2

NP_001355451.1

Confirmed by transcript evidence

NP_510291.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13687955..13695801

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077890.6 → NP_510291.1 Disintegrin and metalloproteinase domain-containing protein adm-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510291.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A3B1E9Z5, G5EDW5

Conserved Domains (4) summary

smart00050
Location:388 → 463

DISIN; Homologues of snake disintegrins

smart00608
Location:465 → 614

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:177 → 371

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:177 → 373

Reprolysin; Reprolysin (M12B) family zinc metalloprotease
NM_001368538.4 → NP_001355451.1 Disintegrin and metalloproteinase domain-containing protein adm-2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

smart00050
Location:388 → 463

DISIN; Homologues of snake disintegrins

smart00608
Location:465 → 614

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:177 → 371

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...