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hlb-1 Liprin-beta homolog [ Caenorhabditis elegans ]

Gene ID: 181499, updated on 2-Nov-2024

Summary

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Official Symbol
hlb-1
Official Full Name
Liprin-beta homolog
Primary source
WormBase:WBGene00011904
Locus tag
CELE_T21H8.1
See related
AllianceGenome:WB:WBGene00011904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in neuromuscular junction development; positive regulation of locomotion; and regulation of nematode pharyngeal pumping. Predicted to be active in presynaptic active zone. Orthologous to human PPFIBP1 (PPFIA binding protein 1) and PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hlb-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
20
Sequence:
Chromosome: X; NC_003284.9 (13865033..13882739, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications. Rosenhahn E, et al. Am J Hum Genet, 2022 Aug 4. PMID 35830857, Free PMC Article
  2. HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans. Wang DY, et al. Neurosci Bull, 2009 Apr. PMID 19290026, Free PMC Article
  3. Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Pekec T, et al. Nat Commun, 2022 Aug 19. PMID 35986016, Free PMC Article
  4. Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent. He KW, et al. Neurosci Bull, 2009 Dec. PMID 19927169, Free PMC Article
  5. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. Serra-Pagès C, et al. J Biol Chem, 1998 Jun 19. PMID 9624153

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Liprin-beta homolog
NP_001123185.1
  • Partially confirmed by transcript evidence
NP_001309703.1
  • Partially confirmed by transcript evidence
NP_001309704.1
  • Partially confirmed by transcript evidence
NP_001309705.1
  • Confirmed by transcript evidence
NP_001309706.1
  • Partially confirmed by transcript evidence
NP_001309707.1
  • Confirmed by transcript evidence
NP_001309708.1
  • Partially confirmed by transcript evidence
NP_001309709.1
  • Confirmed by transcript evidence
NP_001309710.1
  • Partially confirmed by transcript evidence
NP_001309713.1
  • Confirmed by transcript evidence
NP_001309714.1
  • Partially confirmed by transcript evidence
NP_001309716.1
  • Confirmed by transcript evidence
NP_001309717.1
  • Confirmed by transcript evidence
NP_001309718.1
  • Partially confirmed by transcript evidence
NP_001364846.1
  • Partially confirmed by transcript evidence
NP_001379172.1
  • Confirmed by transcript evidence
NP_001380196.1
  • Confirmed by transcript evidence
NP_001380197.1
  • Confirmed by transcript evidence
NP_510311.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13865033..13882739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322656.4 → NP_001309704.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBV4
    Conserved Domains (3) summary
    cd09563
    Location:606 → 669
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:680 → 742
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cl15755
    Location:768 → 839
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_001322647.4 → NP_001309707.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MD98
    Conserved Domains (4) summary
    cd09563
    Location:653 → 716
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:727 → 789
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:815 → 886
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:216 → 427
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001322660.3 → NP_001309706.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MD42
    Conserved Domains (3) summary
    cd09563
    Location:374 → 437
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:448 → 510
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cl15755
    Location:536 → 607
    SAM_superfamily; SAM (Sterile alpha motif )

  4. NM_001322649.4 → NP_001309709.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBE2
    Conserved Domains (4) summary
    cd09563
    Location:627 → 690
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:701 → 763
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:789 → 860
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:190 → 401
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. NM_001322650.3 → NP_001309710.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBC5
    Conserved Domains (4) summary
    cd09563
    Location:669 → 732
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:743 → 805
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:190 → 401
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:831 → 902
    SAM_superfamily; SAM (Sterile alpha motif )

  6. NM_077910.5 → NP_510311.2  Liprin-beta homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510311.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94071
    Conserved Domains (4) summary
    cd09563
    Location:611 → 674
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:685 → 747
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:174 → 385
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:773 → 844
    SAM_superfamily; SAM (Sterile alpha motif )

  7. NM_001129713.4 → NP_001123185.1  Liprin-beta homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123185.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPI2
    Conserved Domains (4) summary
    cd09563
    Location:653 → 716
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:727 → 789
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:174 → 385
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:815 → 886
    SAM_superfamily; SAM (Sterile alpha motif )

  8. NM_001322648.4 → NP_001309708.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A131MBC5, A0A131MBE2, A0A131MBV4, A0A131MBW2, A0A131MBW4, A0A131MBY3, A0A131MBZ3, A0A131MC19, A0A131MC32, A0A131MCT0, A0A131MD42, A0A131MD54, A0A131MD98, A0A131MDA8, A0A131MDI4, A0A131MDJ4, A7LPI2, Q94071, Q94075
    Conserved Domains (4) summary
    cd09563
    Location:695 → 758
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:769 → 831
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:857 → 928
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:216 → 427
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  9. NM_001392878.1 → NP_001380196.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (4) summary
    cd09563
    Location:561 → 624
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:635 → 697
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:124 → 335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:723 → 794
    SAM_superfamily; SAM (Sterile alpha motif )

  10. NM_001377622.2 → NP_001364846.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (4) summary
    cd09563
    Location:603 → 666
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:677 → 739
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:124 → 335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:765 → 836
    SAM_superfamily; SAM (Sterile alpha motif )

  11. NM_001322653.5 → NP_001309713.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MDJ4
    Conserved Domains (4) summary
    cd09563
    Location:474 → 537
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:548 → 610
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:37 → 248
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:636 → 707
    SAM_superfamily; SAM (Sterile alpha motif )

  12. NM_001322654.3 → NP_001309714.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBW2
    Conserved Domains (4) summary
    cd09563
    Location:516 → 579
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:590 → 652
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:37 → 248
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:678 → 749
    SAM_superfamily; SAM (Sterile alpha motif )

  13. NM_001322655.3 → NP_001309703.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MDI4
    Conserved Domains (3) summary
    cd09563
    Location:564 → 627
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:638 → 700
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cl15755
    Location:726 → 797
    SAM_superfamily; SAM (Sterile alpha motif )

  14. NM_001322657.3 → NP_001309717.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MDA8
    Conserved Domains (4) summary
    cd09563
    Location:462 → 525
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:536 → 598
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:25 → 236
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:624 → 695
    SAM_superfamily; SAM (Sterile alpha motif )

  15. NM_001322658.3 → NP_001309718.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBZ3
    Conserved Domains (4) summary
    cd09563
    Location:504 → 567
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:578 → 640
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    COG1196
    Location:25 → 236
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl15755
    Location:666 → 737
    SAM_superfamily; SAM (Sterile alpha motif )

  16. NM_001322659.3 → NP_001309705.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MC19
    Conserved Domains (3) summary
    cd09563
    Location:332 → 395
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:406 → 468
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cl15755
    Location:494 → 565
    SAM_superfamily; SAM (Sterile alpha motif )

  17. NM_001392879.1 → NP_001380197.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

  18. NM_001392880.1 → NP_001379172.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

  19. NM_001322662.1 → NP_001309716.1  Liprin-beta homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MD54
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94071.5

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