elt-3 Transcription factor elt-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: elt-3
Official Full Name: Transcription factor elt-3
Primary source: WormBase:WBGene00001251
Locus tag: CELE_K02B9.4
See related: AllianceGenome:WB:WBGene00001251
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; lysosome organization; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including Caaaaa; Caaaap; hermaphrodite distal tip cell; hypodermis; and rectum. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See elt-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (13934883..13941216)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELT-3 interacts with SKN-1 to activate gst-4 transcription in vitro. elt-3 is required for enhanced gst-4 expression in the brap-2(ok1492) mutant in vivo.
Title: The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2.
Functional validation of a subset of the target genes showed both activating and inhibitory roles of NHR-25 and ELT-3 in regulating their targets.
Title: Collaborative regulation of development but independent control of metabolism by two epidermis-specific transcription factors in Caenorhabditis elegans.
Reconciliation of daf-2 suppression by elt-3 in Caenorhabditis elegans from Tonsaker et al. (2012) and Kim et al. (2012).
Title: Reconciliation of daf-2 suppression by elt-3 in Caenorhabditis elegans from Tonsaker et al. (2012) and Kim et al. (2012).
elt-3 regulates a large number of downstream genes that change expression in old age, including ugt-9, col-144, and sod-3. elt-5(RNAi) and elt-6(RNAi) worms have extended longevity.
Title: An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02B9.4 (e-PCR)
- UniSTS:318297

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor elt-3

NP_001257236.1

Confirmed by transcript evidence

NP_001257237.1

Confirmed by transcript evidence

NP_001367208.1

Confirmed by transcript evidence

NP_001379114.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13934883..13941216

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381138.1 → NP_001367208.1 Transcription factor elt-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B7WN96, E5QCG7, E5QCG8, G5ECF7

Conserved Domains (1) summary

cd00202
Location:243 → 294

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001392881.1 → NP_001379114.1 Transcription factor elt-3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd00202
Location:152 → 203

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001270307.4 → NP_001257236.1 Transcription factor elt-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257236.1

Status: REVIEWED

UniProtKB/TrEMBL

E5QCG7

Conserved Domains (1) summary

cd00202
Location:134 → 185

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001270308.4 → NP_001257237.1 Transcription factor elt-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257237.1

Status: REVIEWED

UniProtKB/TrEMBL

E5QCG8

Conserved Domains (1) summary

cd00202
Location:95 → 146

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C