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cytb-5.1 Cytochrome b5 heme-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181510, updated on 2-Nov-2024

Summary

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Official Symbol
cytb-5.1
Official Full Name
Cytochrome b5 heme-binding domain-containing protein
Primary source
WormBase:WBGene00007848
Locus tag
CELE_C31E10.7
See related
AllianceGenome:WB:WBGene00007848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable heme binding activity. Located in perinuclear region of cytoplasm. Is expressed in intestine. Used to study hematopoietic system disease. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to human CYB5A (cytochrome b5 type A) and CYB5B (cytochrome b5 type B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cytb-5.1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (14001924..14003080)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CCDC93 N-terminal domain-containing protein Neighboring gene CCDC93 N-terminal domain-containing protein Neighboring gene TBC1 domain family member 2B Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene Nematode Specific Peptide family, group A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. Yoshina S, et al. Mol Biol Cell, 2012 May. PMID 22419820, Free PMC Article
  2. Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD. He B, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Mar. PMID 29237573
  3. CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching. Feng Z, et al. Cell Rep, 2020 Sep 8. PMID 32905774
  4. Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans. Raj D, et al. Sci Rep, 2021 Apr 21. PMID 33883621, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cytochrome b5 heme-binding domain-containing protein
NP_510335.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14001924..14003080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077934.9 → NP_510335.2  Cytochrome b5 heme-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510335.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93315
    Conserved Domains (1) summary
    pfam00173
    Location:8 → 80
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
Nucleotide Protein
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