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vha-20 Vacuolar H ATPase [ Caenorhabditis elegans ]

Gene ID: 181526, updated on 2-Nov-2024

Summary

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Official Symbol
vha-20
Official Full Name
Vacuolar H ATPase
Primary source
WormBase:WBGene00010993
Locus tag
CELE_R03E1.2
See related
AllianceGenome:WB:WBGene00010993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signaling receptor activity. Involved in nematode larval development and regulation of intracellular pH. Located in apical plasma membrane. Is expressed in amphid neurons; excretory cell; and intestine. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ATP6AP2 (ATPase H+ transporting accessory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vha-20 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (14163099..14164506, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene WD repeat-containing protein 44 Neighboring gene putative isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prorenin Receptor Homologue VHA-20 is Critical for Intestinal pH Regulation, Ion and Water Management and Larval Development in C. elegans. Zima V, et al. Folia Biol (Praha), 2015. PMID 26667573
  2. The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans. Yochem J, et al. Genetics, 2004 Nov. PMID 15579686, Free PMC Article
  3. Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity. Yu Y, et al. Elife, 2024 Jan 19. PMID 38240316, Free PMC Article
  4. An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development. Miao R, et al. Dev Cell, 2020 Jan 6. PMID 31735670
  5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prorenin receptor homologue VHA-20 is critical for intestinal pH regulation, ion and water management and larval development in C. elegans.
    Title: Prorenin Receptor Homologue VHA-20 is Critical for Intestinal pH Regulation, Ion and Water Management and Larval Development in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bounding membrane of organelle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vacuolar H ATPase
NP_510360.1
  • Product from WormBase gene class vha;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14163099..14164506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077959.7 → NP_510360.1  Vacuolar H ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTY9
    Conserved Domains (1) summary
    pfam07850
    Location:216 → 324
    Renin_r; Renin receptor-like protein
Nucleotide Protein
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