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Pnoc prepronociceptin [ Mus musculus (house mouse) ]

Gene ID: 18155, updated on 2-Nov-2024

Summary

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Official Symbol
Pnocprovided by MGI
Official Full Name
prepronociceptinprovided by MGI
Primary source
MGI:MGI:105308
See related
Ensembl:ENSMUSG00000045731 AllianceGenome:MGI:105308
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N/OFQ; Npnc1; OFQ/N
Summary
This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Expression
Biased expression in whole brain E14.5 (RPKM 9.2), CNS E14 (RPKM 8.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Pnoc in Genome Data Viewer
Location:
14 D1; 14 34.33 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65638931..65662908, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65400673..65425564, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene F-box protein 16 Neighboring gene STARR-seq mESC enhancer starr_36967 Neighboring gene predicted gene, 41178 Neighboring gene STARR-positive B cell enhancer ABC_E4114 Neighboring gene STARR-positive B cell enhancer ABC_E3120 Neighboring gene predicted gene, 48449 Neighboring gene STARR-seq mESC enhancer starr_36972 Neighboring gene zinc finger protein 395 Neighboring gene STARR-positive B cell enhancer mm9_chr14:66008600-66008901 Neighboring gene RIKEN cDNA 9530047P18 gene Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene STARR-seq mESC enhancer starr_36974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66211806-66212040

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Saito Y, et al. Biochem Biophys Res Commun, 1995 Dec 14. PMID 7503733
  2. Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures. Bregola G, et al. J Neurosci, 2002 Nov 15. PMID 12427860, Free PMC Article
  3. A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene. Houtani T, et al. Neurosci Lett, 2003 Jan 2. PMID 12531470
  4. Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice. Binaschi A, et al. Neuroreport, 2003 May 6. PMID 12858040
  5. Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene. Ouagazzal AM, et al. Behav Brain Res, 2003 Sep 15. PMID 12946601

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers.
    Title: Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.
  2. Study demonstrates that nociceptin/orphanin FQ (N/OFQ) activated JNK through the PLC-IP3 signaling pathway, which is coupled to Gi/o, in astrocytes of the spinal dorsal horn. The study also demonstrated that N/OFQ induced monocyte chemoattractant protein-1 release from astrocytes of the spinal cord via JNK activation.
    Title: Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.
  3. the present results suggest that the endogenous OFQ/N/NOP receptor system may modulate the development of cocaine-induced locomotor sensitization.
    Title: The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice.
  4. Data suggest that nociceptin/nociceptin receptor signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.
    Title: Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis.
  5. these findings may identify nociceptin as a novel paracrine mediator of the FSH effects in the regulation of spermatogenesis.
    Title: Nociceptin is upregulated by FSH signaling in Sertoli cells in murine testes.
  6. MPTP increased by about 5-fold the number of neurons expressing ppN/OFQ mRNA in the pars reticulata of the substantia nigra by 24 h after treatment and the elevation remained significant for at least 7 days.
    Title: MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons.
  7. Endogenous nociceptin/orphanin FQ contributes to reserpine-induced parkinsonism.
    Title: Further evidence for an involvement of nociceptin/orphanin FQ in the pathophysiology of Parkinson's disease: a behavioral and neurochemical study in reserpinized mice.
  8. N/OFQ and NOP receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions
    Title: The nociceptin system and hippocampal cognition in mice: a pharmacological and genetic analysis.
  9. reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP receptor system in the modulation of capsaicin effects
    Title: Nociceptin modulates bronchoconstriction induced by sensory nerve activation in mouse lung.
  10. These results demonstrate the interaction between MrgC and N/OFQ-NOP receptor system in pain transmission.
    Title: Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] gamma2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables opioid peptide activity IEA
Inferred from Electronic Annotation
more info
  
enables opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron-neuron synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of pain IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
prepronociceptin
Names
neuropeptide nociceptin 1
orphanin FQ
proorphanin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205075.2 → NP_001192004.1  prepronociceptin isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001192004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to variant 1. This results in a frameshift, and a longer isoform (2, also known as N27K) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC158983
    Consensus CDS
    CCDS88690.1
    UniProtKB/TrEMBL
    B7ZMX9
    Related
    ENSMUSP00000153589.2, ENSMUST00000224594.2
    Conserved Domains (1) summary
    pfam01160
    Location:21 → 65
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

  2. NM_001424488.1 → NP_001411417.1  prepronociceptin isoform 1 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC158983
    UniProtKB/Swiss-Prot
    Q61105, Q61938, Q64387
    UniProtKB/TrEMBL
    Q543U6

  3. NM_001424489.1 → NP_001411418.1  prepronociceptin isoform 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC158983
    UniProtKB/TrEMBL
    B7ZMX9

  4. NM_010932.3 → NP_035062.1  prepronociceptin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_035062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1, also known as N23K).
    Source sequence(s)
    AC158983
    Consensus CDS
    CCDS27213.1
    UniProtKB/Swiss-Prot
    Q61105, Q61938, Q64387
    UniProtKB/TrEMBL
    Q543U6
    Related
    ENSMUSP00000054210.6, ENSMUST00000059339.6
    Conserved Domains (1) summary
    pfam01160
    Location:21 → 65
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65638931..65662908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64387.1 GenPept UniProtKB/Swiss-Prot:Q64387

Gene LinkOut

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