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sucl-1 Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 181570, updated on 2-Nov-2024

Summary

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Official Symbol
sucl-1
Official Full Name
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Primary source
WormBase:WBGene00007350
Locus tag
CELE_C05G5.4
See related
AllianceGenome:WB:WBGene00007350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sucl-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (14754026..14756081)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Matrix-remodeling-associated protein 7 Neighboring gene ncRNA Neighboring gene Metalloprotease TIKI homolog Neighboring gene ncRNA Neighboring gene Carboxypeptidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
  2. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
  3. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
  4. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
  5. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
NP_510450.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14754026..14756081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078049.7 → NP_510450.1  Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510450.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53596
    Conserved Domains (3) summary
    PTZ00187
    Location:5 → 322
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
    pfam00549
    Location:177 → 302
    Ligase_CoA; CoA-ligase
    pfam02629
    Location:31 → 124
    CoA_binding; CoA binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53596.1

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