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C05G5.5 Metalloprotease TIKI homolog [ Caenorhabditis elegans ]

Gene ID: 181571, updated on 2-Nov-2024

Summary

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Official Symbol
C05G5.5
Official Full Name
Metalloprotease TIKI homolog
Primary source
WormBase:WBGene00007351
Locus tag
CELE_C05G5.5
See related
AllianceGenome:WB:WBGene00007351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in negative regulation of Wnt signaling pathway and proteolysis. Predicted to be active in membrane. Orthologous to human TRABD2A (TraB domain containing 2A) and TRABD2B (TraB domain containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See C05G5.5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (14756055..14761121, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Matrix-remodeling-associated protein 7 Neighboring gene ncRNA Neighboring gene Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Neighboring gene ncRNA Neighboring gene Carboxypeptidase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Metalloprotease TIKI homolog
NP_001257247.1
  • Confirmed by transcript evidence
NP_001257248.1
  • Confirmed by transcript evidence
NP_001257249.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14756055..14761121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270318.3 → NP_001257247.1  Metalloprotease TIKI homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257247.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G2V6, H9G2V7, I6U4Y5, Q17678
    Conserved Domains (1) summary
    pfam01963
    Location:36 → 351
    TraB; TraB family

  2. NM_001270319.3 → NP_001257248.1  Metalloprotease TIKI homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257248.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17678
    Conserved Domains (1) summary
    pfam01963
    Location:34 → 228
    TraB; TraB family

  3. NM_001270320.1 → NP_001257249.1  Metalloprotease TIKI homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257249.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17678
    Conserved Domains (1) summary
    pfam01963
    Location:10 → 177
    TraB; TraB family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17678.6

Gene LinkOut

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