nac-1 Sodium-dependent low-affinity dicarboxylate transporter 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: nac-1
Official Full Name: Sodium-dependent low-affinity dicarboxylate transporter 1
Primary source: WormBase:WBGene00003517
Locus tag: CELE_F31F6.6
See related: AllianceGenome:WB:WBGene00003517
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables low-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A2 (solute carrier family 13 member 2) and SLC13A5 (solute carrier family 13 member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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structural and functional characteristics of two sodium-coupled dicarboxylate transporters and their relevance to life span.
Title: Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.

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Function	Evidence Code	Pubs
enables citrate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-affinity sodium:dicarboxylate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in citrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_510473.2

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The following sections contain reference sequences that belong to a specific genome build. Explain