pag-3 Zinc finger protein GFI1 homolog pag-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pag-3
Official Full Name: Zinc finger protein GFI1 homolog pag-3
Primary source: WormBase:WBGene00003909
Locus tag: CELE_F45B8.4
See related: AllianceGenome:WB:WBGene00003909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of secretion by cell; negative regulation of transcription by RNA polymerase II; and neuroblast fate specification. Located in nucleus. Is expressed in several structures, including P1.aap; P11.aaap; P12.aaap; anal region; and neurons. Used to study alcohol use disorder. Orthologous to human ZNF683 (zinc finger protein 683). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pag-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (14950752..14954648, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of PAG-3 results in up-regulation of IDA-1 and other dense core vesicle proteins.
Title: Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F45B8.4 (e-PCR)
- UniSTS:322138

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of forward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zinc finger protein GFI1 homolog pag-3

NP_510480.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14950752..14954648 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078079.6 → NP_510480.1 Zinc finger protein GFI1 homolog pag-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510480.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDE1

Conserved Domains (4) summary

COG5048
Location:164 → 233

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:156 → 176

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:154 → 176

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:196 → 221

zf-H2C2_2; Zinc-finger double domain