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flr-4 Serine/threonine-protein kinase flr-4 [ Caenorhabditis elegans ]

Gene ID: 181604, updated on 2-Nov-2024

Summary

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Official Symbol
flr-4
Official Full Name
Serine/threonine-protein kinase flr-4
Primary source
WormBase:WBGene00001468
Locus tag
CELE_F09B12.6
See related
AllianceGenome:WB:WBGene00001468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in defecation. Located in plasma membrane. Is expressed in intestine; isthmus; and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See flr-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (15089397..15093585)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene UBX domain-containing protein Neighboring gene ncRNA Neighboring gene Low-density lipoprotein receptor-related protein 2 Neighboring gene Movement protein Neighboring gene Putative phospholipase B-like 2 Neighboring gene Palmitoyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegansflr-3(ut9) mutation is a loss-of-function insertion within the drl-1 locus. Honey KL, et al. MicroPubl Biol, 2023. PMID 38116473, Free PMC Article
  2. Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span. Nair T, et al. Aging Cell, 2022 Jan. PMID 35032420, Free PMC Article
  3. A novel gene-diet pair modulates C. elegans aging. Verma S, et al. PLoS Genet, 2018 Aug. PMID 30125273, Free PMC Article
  4. Ultradian rhythm in the intestine of Caenorhabditis elegans is controlled by the C-terminal region of the FLR-1 ion channel and the hydrophobic domain of the FLR-4 protein kinase. Kobayashi Y, et al. Genes Cells, 2011 May. PMID 21518154
  5. FLR-4, a novel serine/threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans. Take-uchi M, et al. Mol Biol Cell, 2005 Mar. PMID 15647385, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans.
    Title: Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans.
  2. We identify a novel gene-diet pair and show that the adaptive capacity to different food-type is modulated by the protein kinase FLR-4. This protein prevents differential activation of the p38 MAPK pathway dependent on the food-type and consequently, the expression of cytoprotective genes by transcription factor NHR-8.
    Title: A novel gene-diet pair modulates C. elegans aging.
  3. Data show that FLR-1 and FLR-4 are often colocalized in the plasma membrane.
    Title: Ultradian rhythm in the intestine of Caenorhabditis elegans is controlled by the C-terminal region of the FLR-1 ion channel and the hydrophobic domain of the FLR-4 protein kinase.
  4. flr4 acts in the intestine to increase the length of defecation cycle periods
    Title: FLR-4, a novel serine/threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Serine/threonine-protein kinase flr-4
NP_510508.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15089397..15093585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078107.6 → NP_510508.1  Serine/threonine-protein kinase flr-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510508.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NLA1
    Conserved Domains (2) summary
    smart00220
    Location:40 → 323
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:40 → 323
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NLA1.1

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