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unc-7 Innexin;Innexin unc-7 [ Caenorhabditis elegans ]

Gene ID: 181608, updated on 2-Nov-2024

Summary

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Official Symbol
unc-7
Official Full Name
Innexin;Innexin unc-7
Primary source
WormBase:WBGene00006747
Locus tag
CELE_R07D5.1
See related
AllianceGenome:WB:WBGene00006747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables gap junction channel activity. Involved in several processes, including egg-laying behavior; response to anesthetic; and spicule insertion. Located in gap junction and neuron projection membrane. Is expressed in several structures, including intestine; muscle cell; nervous system; and pharyngeal gland cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (15120846..15147740, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans. Nakayama A, et al. Proc Natl Acad Sci U S A, 2024 May 21. PMID 38753507,
  2. OPUS: a growing family of gap junction proteins? Barnes TM. Trends Genet, 1994 Sep. PMID 7974741
  3. A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel. Bouhours M, et al. Mol Brain, 2011 Apr 13. PMID 21489288, Free PMC Article
  4. Molecular basis of junctional current rectification at an electrical synapse. Shui Y, et al. Sci Adv, 2020 Jul. PMID 32923588, Free PMC Article
  5. Distinct roles for innexin gap junctions and hemichannels in mechanosensation. Walker DS, et al. Elife, 2020 Jan 29. PMID 31995033, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study showed that isoform, which perturbs DOP-2 signaling in the PCB neuron and its electrical partner, hook neurons.
    Title: DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation.
  2. UNC-7S and UNC-9 are widely expressed and contribute to a large number of the gap junctions identified in the locomotory.nervous system.
    Title: Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system.
  3. UNC-7 is localized perisynaptically throughout development and is required in presynaptic neurons to regulate active zone differentiation.
    Title: Caenorhabditis elegans innexins regulate active zone differentiation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gap junction channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gap junction channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables gap junction hemi-channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to dopamine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gap junction assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of male mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuronal signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to anesthetic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spicule insertion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in gap junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gap junction IEA
Inferred from Electronic Annotation
more info
  
located_in gap junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in neuron projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Innexin;Innexin unc-7
NP_001257255.1
  • Confirmed by transcript evidence
NP_001257256.1
  • Partially confirmed by transcript evidence
NP_001337312.1
  • Partially confirmed by transcript evidence
NP_001337313.1
  • Partially confirmed by transcript evidence
NP_001337316.1
  • Partially confirmed by transcript evidence
NP_001337317.1
  • Partially confirmed by transcript evidence
NP_001337318.1
  • Confirmed by transcript evidence
NP_001337319.1
  • Confirmed by transcript evidence
NP_001337320.1
  • Confirmed by transcript evidence
NP_001379507.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15120846..15147740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350356.3 → NP_001337319.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUM7
    Conserved Domains (1) summary
    pfam00876
    Location:93 → 453
    Innexin

  2. NM_001270326.3 → NP_001257255.1  Innexin unc-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257255.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03412
    Conserved Domains (1) summary
    pfam00876
    Location:139 → 501
    Innexin; Innexin

  3. NM_001350352.4 → NP_001337313.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUM1
    Conserved Domains (1) summary
    pfam00876
    Location:163 → 523
    Innexin

  4. NM_001350354.3 → NP_001337317.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUM6
    Conserved Domains (1) summary
    pfam00876
    Location:80 → 440
    Innexin

  5. NM_001392896.1 → NP_001379507.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8JQR8
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 380
    Innexin

  6. NM_001350353.4 → NP_001337312.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUM5
    Conserved Domains (1) summary
    pfam00876
    Location:163 → 525
    Innexin

  7. NM_001350355.3 → NP_001337316.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUM3
    Conserved Domains (1) summary
    pfam00876
    Location:80 → 442
    Innexin

  8. NM_001350357.3 → NP_001337318.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUM9
    Conserved Domains (1) summary
    pfam00876
    Location:93 → 455
    Innexin

  9. NM_001350358.3 → NP_001337320.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUN4
    Conserved Domains (1) summary
    pfam00876
    Location:139 → 499
    Innexin

  10. NM_001270327.3 → NP_001257256.1  Innexin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8JQR7
    Conserved Domains (1) summary
    pfam00876
    Location:71 → 433
    Innexin; Innexin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03412.1

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