pkhm-2 PH domain-containing protein;RUN domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pkhm-2
Official Full Name: PH domain-containing protein;RUN domain-containing protein
Primary source: WormBase:WBGene00011680
Locus tag: CELE_T10B10.3
See related: AllianceGenome:WB:WBGene00011680
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable kinesin binding activity. Predicted to be involved in Golgi organization; lysosome localization; and regulation of protein localization. Predicted to be located in lysosome. Predicted to be active in endosome membrane. Is expressed in anterior gonad arm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pkhm-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (15178096..15181465, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T10B10.3 (e-PCR)
- UniSTS:307991

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PH domain-containing protein;RUN domain-containing protein

NP_001408270.1

Partially confirmed by transcript evidence

NP_510523.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15178096..15181465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078122.6 → NP_510523.1 RUN domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510523.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22368

Conserved Domains (2) summary

smart00233
Location:515 → 607

PH; Pleckstrin homology domain

pfam00169
Location:515 → 608

PH; PH domain
NM_001421342.1 → NP_001408270.1 PH domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QCL7