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famk-1 Extracellular serine/threonine protein kinase CeFam20 [ Caenorhabditis elegans ]

Gene ID: 181616, updated on 2-Nov-2024

Summary

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Official Symbol
famk-1
Official Full Name
Extracellular serine/threonine protein kinase CeFam20
Primary source
WormBase:WBGene00010356
Locus tag
CELE_H03A11.1
See related
AllianceGenome:WB:WBGene00010356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables manganese ion binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Predicted to be located in Golgi membrane and extracellular region. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including body wall musculature; gonad; oocyte; rectum; and vulva. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1G. Orthologous to several human genes including FAM20A (FAM20A golgi associated secretory pathway pseudokinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See famk-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (15209289..15213259, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the Golgi casein kinase. Xiao J, et al. Proc Natl Acad Sci U S A, 2013 Jun 25. PMID 23754375, Free PMC Article
  2. Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. Gerson-Gurwitz A, et al. J Cell Biol, 2019 Nov 4. PMID 31541016, Free PMC Article
  3. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Extracellular serine/threonine protein kinase CeFam20
NP_510527.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15209289..15213259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078126.5 → NP_510527.1  Extracellular serine/threonine protein kinase CeFam20 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTW2
    Conserved Domains (2) summary
    pfam06702
    Location:260 → 474
    Fam20C; Golgi casein kinase, C-terminal, Fam20
    pfam15051
    Location:218 → 239
    FAM198; FAM198 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XTW2.1

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