kin-20 Casein kinase I isoform delta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kin-20
Official Full Name: Casein kinase I isoform delta
Primary source: WormBase:WBGene00002203
Locus tag: CELE_F46F2.2
See related: AllianceGenome:WB:WBGene00002203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine kinase activity. Involved in regulation of collateral sprouting and regulation of locomotion. Located in adherens junction and nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 2 and invasive ductal carcinoma. Orthologous to several human genes including TPTEP2-CSNK1E (TPTEP2-CSNK1E readthrough) and CSNK1E (casein kinase 1 epsilon). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kin-20 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (15268602..15277764, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clock gene homologs lin-42 and kin-20 regulate circadian rhythms in C. elegans.
Title: Clock gene homologs lin-42 and kin-20 regulate circadian rhythms in C. elegans.
Worms containing a large deletion in kin-20 have a significantly smaller brood size and develop slower than wild type C. elegans. kin-20 is important for post-transcriptional regulation of mature let-7 and lin-4 microRNA expression.
Title: The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans.
tim-1 and kin-20, the C. elegans homologs of the Drosophila circadian clock genes timeless and doubletime, respectively, are required to maintain late-larval identity and prevent premature expression of adult cell fates.
Title: Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F46F2.2 (e-PCR)
- UniSTS:311246

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Casein kinase I isoform delta

NP_001024669.1

Confirmed by transcript evidence

NP_001359567.1

Confirmed by transcript evidence

NP_001360748.1

Partially confirmed by transcript evidence

NP_001362050.1

Confirmed by transcript evidence

NP_001367127.1

Confirmed by transcript evidence

NP_001370884.1

Partially confirmed by transcript evidence

NP_872247.4

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15268602..15277764 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381166.1 → NP_001367127.1 Casein kinase I isoform delta [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14125
Location:190 → 463

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001373594.3 → NP_001359567.1 Casein kinase I isoform delta [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14125
Location:190 → 463

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001029498.6 → NP_001024669.1 Casein kinase I isoform delta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024669.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A4V0IKI0, H9G2V4, H9G2V5, Q20471, Q2PJ71, Q565A9, Q5MCN7, Q5MCN8, Q5WRP4, Q8I4I6

Conserved Domains (2) summary

smart00220
Location:191 → 421

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14125
Location:190 → 463

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_182447.10 → NP_872247.4 Casein kinase I isoform delta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872247.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20471

Conserved Domains (2) summary

smart00220
Location:9 → 239

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14125
Location:8 → 281

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001375178.1 → NP_001362050.1 Casein kinase I isoform delta [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14125
Location:8 → 281

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001383681.1 → NP_001370884.1 Casein kinase I isoform delta [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14125
Location:8 → 281

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001373595.3 → NP_001360748.1 Casein kinase I isoform delta [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14125
Location:19 → 292

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon