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Ctnnd2 catenin delta 2 [ Mus musculus (house mouse) ]

Gene ID: 18163, updated on 2-Nov-2024

Summary

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Official Symbol
Ctnnd2provided by MGI
Official Full Name
catenin delta 2provided by MGI
Primary source
MGI:MGI:1195966
See related
Ensembl:ENSMUSG00000022240 AllianceGenome:MGI:1195966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nprap; Catnd2; neurojugin
Summary
Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be a structural constituent of postsynaptic density. Acts upstream of or within learning; morphogenesis of a branching structure; and regulation of synaptic plasticity. Located in postsynaptic density. Is expressed in several structures, including central nervous system; future brain; lung; sensory organ; and spinal ganglion. Human ortholog(s) of this gene implicated in anxiety disorder; major depressive disorder; and schizophrenia. Orthologous to human CTNND2 (catenin delta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 25.6), frontal lobe adult (RPKM 25.1) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Ctnnd2 in Genome Data Viewer
Location:
15 B2; 15 12.02 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (30172680..31029490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (30172534..31029344)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38264 Neighboring gene STARR-seq mESC enhancer starr_38265 Neighboring gene STARR-seq mESC enhancer starr_38266 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene predicted gene, 26163 Neighboring gene STARR-seq mESC enhancer starr_38267 Neighboring gene predicted gene, 31953 Neighboring gene STARR-seq mESC enhancer starr_38270 Neighboring gene STARR-seq mESC enhancer starr_38272 Neighboring gene STARR-seq mESC enhancer starr_38273 Neighboring gene STARR-seq mESC enhancer starr_38274 Neighboring gene VISTA enhancer mm1400 Neighboring gene STARR-seq mESC enhancer starr_38276 Neighboring gene predicted gene, 41284 Neighboring gene STARR-positive B cell enhancer ABC_E10846 Neighboring gene STARR-seq mESC enhancer starr_38278 Neighboring gene predicted gene, 24487 Neighboring gene STARR-seq mESC enhancer starr_38279 Neighboring gene predicted gene, 31841 Neighboring gene STARR-seq mESC enhancer starr_38280 Neighboring gene RIKEN cDNA 9630009A06 gene Neighboring gene predicted gene, 53868 Neighboring gene RIKEN cDNA 4930430F21 gene Neighboring gene predicted gene, 32011

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice. Xu M, et al. Brain Behav, 2023 Jul. PMID 37226399, Free PMC Article
  2. The autism-associated loss of δ-catenin functions disrupts social behavior. Mendez-Vazquez H, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216537, Free PMC Article
  3. delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development. Ho C, et al. J Comp Neurol, 2000 May 1. PMID 10753311
  4. Expression of the mRNA for two isoforms of neural plakophilin-related arm-repeat protein/delta-catenin in rodent neurons and glial cells. Kawamura Y, et al. Neurosci Lett, 1999 Dec 31. PMID 10626844
  5. Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo. Matter C, et al. Neuron, 2009 Nov 12. PMID 19914181, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.
    Title: Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.
  2. Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
    Title: Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
  3. microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting delta-catenin, a novel catenin in asthma.
    Title: microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting δ-catenin, a novel catenin in asthma.
  4. the hypoxia-inducible transcriptional factor, HIF1alpha, can directly upregulate the expression of the gene Ctnnd2, which codes the protein delta-Catenin.
    Title: Hypoxia induced δ-Catenin to enhance mice hepatocellular carcinoma progression via Wnt signaling.
  5. delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
    Title: δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
  6. Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation.
    Title: δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.
  7. Acute knockdown of delta-catenin leads to increases in spine and synapse density in hippocampal neurons during development.
    Title: Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.
  8. conditional targeting of p120 catenin in mice leads to progressive development of skin neoplasias associated with intrinsic NF-kappaB activation.
    Title: Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.
  9. Delta-catenin occurs in mouse brain dendrites along with PSD-95 in postsynaptic scaffolds. It forms stable complexes with glutamate receptors, suggesting a link between delta-catenin and glutamatergic synaptic transmission during neuronal development.
    Title: Glutamate-induced delta-catenin redistribution and dissociation from postsynaptic receptor complexes.
  10. PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability.
    Title: Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within morphogenesis of a branching structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
catenin delta-2
Names
catenin (cadherin associated protein), delta 2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
neural plakophilin-related arm-repeat protein
neurojungin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355502.2 → NP_001342431.1  catenin delta-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC124993, AC134414, AC139197
    Consensus CDS
    CCDS88745.1
    UniProtKB/Swiss-Prot
    B2RR80, O35927
    UniProtKB/TrEMBL
    B7ZNF6
    Related
    ENSMUSP00000154410.2, ENSMUST00000226119.2
    Conserved Domains (5) summary
    smart00185
    Location:577 → 617
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:830 → 871
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:548 → 573
    ARM; armadillo repeat [structural motif]
    cl26464
    Location:256 → 530
    Atrophin-1; Atrophin-1 family
    cl27106
    Location:546 → 719
    PLN03200; cellulose synthase-interactive protein; Provisional

  2. NM_001411452.1 → NP_001398381.1  catenin delta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC134414, AC139197

  3. NM_001411453.1 → NP_001398382.1  catenin delta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC134414, AC139197

  4. NM_008729.3 → NP_032755.2  catenin delta-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC124993, AC134414, AC139197
    Consensus CDS
    CCDS27405.1
    UniProtKB/Swiss-Prot
    B2RR80, O35927
    UniProtKB/TrEMBL
    E9QKH8
    Related
    ENSMUSP00000080427.6, ENSMUST00000081728.7
    Conserved Domains (3) summary
    cd00020
    Location:540 → 662
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam17052
    Location:1050 → 1109
    CAF20; Cap associated factor
    sd00043
    Location:548 → 573
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    30172680..31029490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520033.4 → XP_006520096.1  catenin delta-2 isoform X1

    UniProtKB/Swiss-Prot
    B2RR80, O35927
    Conserved Domains (5) summary
    smart00185
    Location:486 → 526
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:455 → 628
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:45 → 452
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:457 → 482
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:739 → 779
    Arm; Armadillo/beta-catenin-like repeat

  2. XM_030248378.2 → XP_030104238.1  catenin delta-2 isoform X1

    UniProtKB/Swiss-Prot
    B2RR80, O35927
    Conserved Domains (5) summary
    smart00185
    Location:486 → 526
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:455 → 628
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:45 → 452
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:457 → 482
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:739 → 779
    Arm; Armadillo/beta-catenin-like repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35927.1 GenPept UniProtKB/Swiss-Prot:O35927

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