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psa-3 Transcriptional coregulator psa-3 [ Caenorhabditis elegans ]

Gene ID: 181631, updated on 2-Nov-2024

Summary

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Official Symbol
psa-3
Official Full Name
Transcriptional coregulator psa-3
Primary source
WormBase:WBGene00009560
Locus tag
CELE_F39D8.2
See related
AllianceGenome:WB:WBGene00009560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables transcription coactivator binding activity. Involved in regulation of asymmetric cell division. Located in nucleus. Is expressed in several structures, including P1; P10; TL.aa; TR.aa; and hypodermal cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See psa-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (15407931..15419298)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Spaetzle domain-containing protein Neighboring gene Zinc metalloproteinase nas-13 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila. Bhambhani C, et al. PLoS Genet, 2014 Feb. PMID 24516405, Free PMC Article
  2. Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans. Arata Y, et al. Dev Cell, 2006 Jul. PMID 16824957
  3. Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution. Mukherjee K, et al. J Mol Evol, 2007 Aug. PMID 17665086
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nob-1/Hox, ceh-20/Pbx, and a Meis-related gene, psa-3, are required for asymmetric division of the T hypodermal cell.
    Title: Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transcriptional coregulator psa-3
NP_001076765.2
  • Confirmed by transcript evidence
NP_001076766.1
  • Confirmed by transcript evidence
NP_001257263.1
  • Confirmed by transcript evidence
NP_001300347.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15407931..15419298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083296.5 → NP_001076765.2  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3ASQ5, D5MNM8, G5EFB3, Q0G825
    Conserved Domains (1) summary
    pfam16493
    Location:92 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. NM_001083297.5 → NP_001076766.1  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076766.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFB3
    Conserved Domains (1) summary
    pfam16493
    Location:58 → 118
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. NM_001270334.3 → NP_001257263.1  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257263.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5MNM8
    Conserved Domains (1) summary
    pfam16493
    Location:26 → 86
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  4. NM_001313418.3 → NP_001300347.1  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASQ5
Nucleotide Protein
Heading Accession and Version

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