gas-1 putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gas-1
Official Full Name: putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Primary source: WormBase:WBGene00001520
Locus tag: CELE_K09A9.5
See related: AllianceGenome:WB:WBGene00001520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NAD binding activity; and NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and response to xenobiotic stimulus. Located in intracellular membrane-bounded organelle. Is expressed in anterior gonad arm; body wall musculature; nervous system; non-striated muscle; and tail. Used to study alcohol use disorder and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gas-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (15586786..15590397, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

high levels of complex II negatively regulate longevity in gas-1(fc21) mutant by decreasing the stability of complex I.
Title: Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant.
mutation in a subunit of complex I of the mitochondrial electron transport chain (gas-1) causes Caenorhabditis elegans to be hypersensitive to volatile anesthetics and oxygen as well as shortening lifespan
Title: The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K09A9.5 (e-PCR)
- UniSTS:307797

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

NP_510569.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15586786..15590397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078168.6 → NP_510569.1 putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510569.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93873

Conserved Domains (2) summary

PRK06075
Location:93 → 482

PRK06075; NADH dehydrogenase subunit D; Validated

COG0649
Location:90 → 482

NuoD; NADH:ubiquinone oxidoreductase 49 kD subunit (chain D) [Energy production and conversion]