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gpn-1 GlyPicaN [ Caenorhabditis elegans ]

Gene ID: 181658, updated on 2-Nov-2024

Summary

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Official Symbol
gpn-1
Official Full Name
GlyPicaN
Primary source
WormBase:WBGene00001687
Locus tag
CELE_F59D12.4
See related
AllianceGenome:WB:WBGene00001687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including epidermis morphogenesis; nematode larval development; and neuron migration. Predicted to be located in collagen-containing extracellular matrix and plasma membrane. Predicted to be active in cell surface. Is expressed in intestine; neuroblasts; pharynx; and ventral cord neurons. Human ortholog(s) of this gene implicated in Keipert syndrome and omodysplasia 1. Orthologous to several human genes including GPC1 (glypican 1); GPC2 (glypican 2); and GPC4 (glypican 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (15681693..15687477)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PITH domain-containing protein;Thioredoxin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GPN-1/glypican and UNC-52/perlecan do not appear to function in BMP signaling to pattern the C. elegans postembryonic mesoderm. DeGroot MS, et al. MicroPubl Biol, 2021. PMID 34405137, Free PMC Article
  2. Regulation of TGFβ superfamily signaling by two separable domains of glypican LON-2 in C. elegans. Taneja-Bageshwar S, et al. Worm, 2013 Jul 1. PMID 24778932, Free PMC Article
  3. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Gumienny TL, et al. Curr Biol, 2007 Jan 23. PMID 17240342
  4. Extracellular sugar modifications provide instructive and cell-specific information for axon-guidance choices. Bülow HE, et al. Curr Biol, 2008 Dec 23. PMID 19062279, Free PMC Article
  5. Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development. Kinnunen TK. PLoS One, 2014. PMID 25054285, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermis morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GlyPicaN
NP_510582.1
  • Product from WormBase gene class gpn;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15681693..15687477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078181.4 → NP_510582.1  GlyPicaN [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510582.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGU4
    Conserved Domains (1) summary
    pfam01153
    Location:43 → 414
    Glypican; Glypican
Nucleotide Protein
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Gene LinkOut

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