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Npy1r neuropeptide Y receptor Y1 [ Mus musculus (house mouse) ]

Gene ID: 18166, updated on 2-Nov-2024

Summary

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Official Symbol
Npy1rprovided by MGI
Official Full Name
neuropeptide Y receptor Y1provided by MGI
Primary source
MGI:MGI:104963
See related
Ensembl:ENSMUSG00000036437 AllianceGenome:MGI:104963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npyr; Y1-R; NPY1-R
Summary
Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within several processes, including feeding behavior; glucose metabolic process; and sensory perception of pain. Predicted to be located in axon and synaptic vesicle. Predicted to be active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; immune system; and liver. Used to study obesity. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 14.0), cortex adult (RPKM 4.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Npy1r in Genome Data Viewer
Location:
8 B3.1; 8 33.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (67149595..67159452)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (66697149..66706800)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transketolase-like 2 Neighboring gene STARR-seq mESC enhancer starr_21675 Neighboring gene STARR-seq mESC enhancer starr_21676 Neighboring gene STARR-seq mESC enhancer starr_21677 Neighboring gene neuropeptide Y receptor Y5 Neighboring gene STARR-seq mESC enhancer starr_21679 Neighboring gene STARR-positive B cell enhancer ABC_E8235 Neighboring gene RNA binding motif protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21680 Neighboring gene nuclear assembly factor 1 ribonucleoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of estrous cycle and sex on the expression of neuropeptide Y Y1 receptor in discrete hypothalamic and limbic nuclei of transgenic mice. Martini M, et al. Peptides, 2011 Jun. PMID 21514339
  2. Ablation of Y1 receptor impairs osteoclast bone-resorbing activity. Sousa DM, et al. Sci Rep, 2016 Sep 20. PMID 27646989, Free PMC Article
  3. Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice. Statello R, et al. Physiol Behav, 2017 Apr 1. PMID 27474416
  4. Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. Howell OW, et al. J Neurochem, 2003 Aug. PMID 12859678
  5. Induced down-regulation of neuropeptide Y-Y1 receptors delays initiation of kindling. Benmaamar R, et al. Eur J Neurosci, 2003 Aug. PMID 12925003

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch.
    Title: The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch.
  2. Hypothalamic NPY-Y1R Interacts with Gonadal Hormones in Protecting Female Mice against Obesity and Neuroinflammation.
    Title: Hypothalamic NPY-Y1R Interacts with Gonadal Hormones in Protecting Female Mice against Obesity and Neuroinflammation.
  3. NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression.
    Title: NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression.
  4. Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice.
    Title: Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice.
  5. Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions.
    Title: Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions.
  6. this study demonstrates that Y1 receptor signaling negatively regulates insulin release
    Title: Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism.
  7. This study showed that the Npy1r(Y5R-/-) male mice display decreased 5-hydroxytriptamine (5-HT) positive fibres and increased baseline neural activity in orbitofrontal cortex.
    Title: Conditional inactivation of Npy1r gene in mice induces behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram.
  8. the lack of Y1Rs stimulates the formation of larger multinucleated osteoclasts in vitro with reduced bone-resorbing activity.
    Title: Ablation of Y1 receptor impairs osteoclast bone-resorbing activity.
  9. Knockdown of the Y1 receptor induces alkaline phosphatase activity and mineralization of MC3T3-E1 cells.
    Title: Inhibition of neuropeptide Y Y1 receptor induces osteoblast differentiation in MC3T3‑E1 cells.
  10. NPY deficient mice had significantly impaired Hematopoietic stem/progenitor cell (HSPC) mobilization due to increased expression of HSPC maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9) activity in bone marrow.
    Title: Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (11)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuropeptide Y receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pancreatic polypeptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide YY receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT acts_upstream_of_or_within feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in peristalsis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to morphine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic signaling via neuropeptide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuropeptide Y receptor type 1
Names
NPY-1 receptor
neuropeptide Y receptor subtype

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358955.1 → NP_001345884.1  neuropeptide Y receptor type 1

    Status: VALIDATED

    Source sequence(s)
    AC116731
    Consensus CDS
    CCDS22336.1
    UniProtKB/Swiss-Prot
    Q04573, Q61993
    UniProtKB/TrEMBL
    Q3V1K5
    Conserved Domains (1) summary
    cd15395
    Location:40 → 330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_010934.4 → NP_035064.1  neuropeptide Y receptor type 1

    See identical proteins and their annotated locations for NP_035064.1

    Status: VALIDATED

    Source sequence(s)
    AC116731
    Consensus CDS
    CCDS22336.1
    UniProtKB/Swiss-Prot
    Q04573, Q61993
    UniProtKB/TrEMBL
    Q3V1K5
    Related
    ENSMUSP00000045530.6, ENSMUST00000039303.7
    Conserved Domains (1) summary
    cd15395
    Location:40 → 330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    67149595..67159452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509594.5 → XP_006509657.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006509657.1

    UniProtKB/Swiss-Prot
    Q04573, Q61993
    UniProtKB/TrEMBL
    Q3V1K5
    Conserved Domains (1) summary
    cd15395
    Location:40 → 330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006509595.5 → XP_006509658.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006509658.1

    UniProtKB/Swiss-Prot
    Q04573, Q61993
    UniProtKB/TrEMBL
    Q3V1K5
    Related
    ENSMUSP00000148417.2, ENSMUST00000212588.2
    Conserved Domains (1) summary
    cd15395
    Location:40 → 330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_036153812.1 → XP_036009705.1  neuropeptide Y receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    Q04573, Q61993
    UniProtKB/TrEMBL
    Q3V1K5
    Conserved Domains (1) summary
    cd15395
    Location:40 → 330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_036153811.1 → XP_036009704.1  neuropeptide Y receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    Q04573, Q61993
    UniProtKB/TrEMBL
    Q3V1K5
    Conserved Domains (1) summary
    cd15395
    Location:40 → 330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04573.1 GenPept UniProtKB/Swiss-Prot:Q04573

Gene LinkOut

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