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mec-5 Uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 181678, updated on 2-Nov-2024

Summary

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Official Symbol
mec-5
Official Full Name
Uncharacterized protein
Primary source
WormBase:WBGene00003169
Locus tag
CELE_E03G2.3
See related
AllianceGenome:WB:WBGene00003169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be an extracellular matrix structural constituent. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Located in extracellular matrix. Is expressed in several structures, including hypodermis; intestine; muscle cell; nervous system; and tail. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mec-5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (15944009..15948952)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ABC transmembrane type-1 domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Emtage L, et al. Neuron, 2004 Dec 2. PMID 15572111
  2. Extracellular proteins needed for C. elegans mechanosensation. Du H, et al. Neuron, 1996 Jan. PMID 8562083
  3. Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons. Cueva JG, et al. J Neurosci, 2007 Dec 19. PMID 18094248, Free PMC Article
  4. Neuron-epidermal attachment protects hyper-fragile axons from mechanical strain. Bonacossa-Pereira I, et al. Cell Rep, 2022 Mar 8. PMID 35263583
  5. Touch-induced mechanical strain in somatosensory neurons is independent of extracellular matrix mutations in Caenorhabditis elegans. Nekimken AL, et al. Mol Biol Cell, 2020 Jul 21. PMID 32579427, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mechanosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mechanosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Uncharacterized protein
NP_741941.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15944009..15948952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171808.6 → NP_741941.1  Uncharacterized protein CELE_E03G2.3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741941.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFQ9
    Conserved Domains (1) summary
    pfam01391
    Location:136 → 194
    Collagen; Collagen triple helix repeat (20 copies)
Nucleotide Protein
Heading Accession and Version

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