mua-6 Intermediate filament protein ifa-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mua-6
Official Full Name: Intermediate filament protein ifa-2
Primary source: WormBase:WBGene00003485
Locus tag: CELE_W10G6.3
See related: AllianceGenome:WB:WBGene00003485
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of cytoskeleton. Involved in cell-cell adhesion. Located in hemidesmosome. Is expressed in hypodermis; neurons; and uterus. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mua-6 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (16262289..16265686, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the head domain contains redundant signals for IF localization, whereas non-redundant essential functions map to the IFA-2 tail, although the tail is unlikely to be directly involved in fibrous organelle localization.
Title: The tail domain is essential but the head domain dispensable for C. elegans intermediate filament IFA-2 function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W10G6.3 (e-PCR)
- UniSTS:311173

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Intermediate filament protein ifa-2

NP_510648.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

16262289..16265686 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078247.9 → NP_510648.1 Intermediate filament protein ifa-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510648.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02365

Conserved Domains (4) summary

pfam00038
Location:71 → 419

Filament; Intermediate filament protein

pfam00932
Location:462 → 570

LTD; Lamin Tail Domain

pfam04871
Location:141 → 203

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

pfam16046
Location:176 → 263

FAM76; FAM76 protein