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ser-1 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181716, updated on 2-Nov-2024

Summary

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Official Symbol
ser-1
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00004776
Locus tag
CELE_F59C12.2
See related
AllianceGenome:WB:WBGene00004776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in several processes, including calcium-mediated signaling; egg-laying behavior; and serotonin receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including egg-laying apparatus; intestine; neurons; pharyngeal muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and steatotic liver disease (multiple). Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A) and HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ser-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (16579745..16587624)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Val

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a novel serotonin receptor from Caenorhabditis elegans: cloning and expression of two splice variants. Hamdan FF, et al. J Neurochem, 1999 Apr. PMID 10098838
  2. The serotonin receptor SER-1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans. Dernovici S, et al. Dev Neurobiol, 2007 Feb 1. PMID 17443782
  3. A microbial metabolite synergizes with endogenous serotonin to trigger C. elegans reproductive behavior. Chen YC, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199611, Free PMC Article
  4. Dual excitatory and inhibitory serotonergic inputs modulate egg laying in Caenorhabditis elegans. Hapiak VM, et al. Genetics, 2009 Jan. PMID 19001289, Free PMC Article
  5. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Teixeira-Castro A, et al. Brain, 2015 Nov. PMID 26373603, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The serotonin receptor SER-1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans.
    Title: The serotonin receptor SER-1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans.
  2. These studies suggest that the SER-1/MPZ-1 interaction facilitates SER-1 mediated signaling.
    Title: SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled amine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to nitrogen compound IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of chemical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_001024728.1
  • Confirmed by transcript evidence
NP_001024729.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16579745..16587624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029557.5 → NP_001024728.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024728.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17470, Q21034
    Conserved Domains (1) summary
    cd15052
    Location:56 → 438
    7tmA_5-HT2; serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001029558.5 → NP_001024729.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024729.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECV2
    Conserved Domains (1) summary
    cd15052
    Location:8 → 390
    7tmA_5-HT2; serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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