ain-1 ALG-1 INteracting protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ain-1
Official Full Name: ALG-1 INteracting protein
Primary source: WormBase:WBGene00015547
Locus tag: CELE_C06G1.4
See related: AllianceGenome:WB:WBGene00015547
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including negative regulation of gene expression; regulation of development, heterochronic; and regulation of vulval development. Located in P-body. Is expressed widely. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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We show in vitro and in vivo that their mutations severely altered the association with AIN-1 and AIN-2. our results demonstrate that the microRNA pathway can act independently of GW182 proteins during C. elegans embryogenesis
Title: GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.
AIN-1 is selectively degraded by autophagy.
Title: Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans.
AIN-1 interacts with Argonaute proteins through GW repeats in the middle region of the protein.
Title: The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.
let-7 represses translation initiation in Caenorhabditis elegans which requires the GW182 proteins AIN-1 and AIN-2.
Title: Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins.
GW182 family proteins AIN-1 and AIN-2 act redundantly to regulate the expression of miRNA targets, but not miRNA biogenesis.
Title: Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.
AIN-1 gene is identified and found to regulate developmental timing [AIN-1]
Title: The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of translational initiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of development, heterochronic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed