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aak-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 [ Caenorhabditis elegans ]

Gene ID: 181727, updated on 2-Nov-2024

Summary

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Official Symbol
aak-2
Official Full Name
5'-AMP-activated protein kinase catalytic subunit alpha-2
Primary source
WormBase:WBGene00020142
Locus tag
CELE_T01C8.1
See related
AllianceGenome:WB:WBGene00020142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables AMP-activated protein kinase activity. Involved in several processes, including determination of adult lifespan; nematode pharyngeal pumping; and regulation of protein secretion. Located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including body wall musculature; excretory cell; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; and type 2 diabetes mellitus. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) and PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aak-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (16796087..16803398)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Aspartate aminotransferase, cytoplasmic Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Degenerin mec-4 Neighboring gene Adenylyl cyclase-associated protein;C-CAP/cofactor C-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An AMPK biosensor for Caenorhabditis elegans. Carman L, et al. MicroPubl Biol, 2022. PMID 35874603, Free PMC Article
  2. Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans. LaRue BL, et al. PLoS One, 2011 Feb 3. PMID 21304820, Free PMC Article
  3. Tissue-specific heteroplasmy segregation is accompanied by a sharp mtDNA decline in Caenorhabditis elegans soma. Tsyba N, et al. iScience, 2023 Apr 21. PMID 36968071, Free PMC Article
  4. Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease. Lim MA, et al. J Neurosci, 2012 Jan 18. PMID 22262909, Free PMC Article
  5. Extension of C. elegans lifespan using the ·NO-delivery dinitrosyl iron complexes. Huang HW, et al. J Biol Inorg Chem, 2018 Jul. PMID 29858679

See all (206) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ROS-mediated relationships between metabolism and DAF-16 subcellular localization in Caenorhabditis elegans revealed by a novel fluorometric method.
    Title: ROS-mediated relationships between metabolism and DAF-16 subcellular localization in Caenorhabditis elegans revealed by a novel fluorometric method.
  2. AMPK functions downstream of, or in parallel with DAF-18/PTEN and insulin/IGF-1 signaling to inhibit PP2A function.
    Title: C. elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-insulin-PP2A-MAPK pathway.
  3. mir-259 functioned in pharynx-intestinal valve and RSKS-1 functioned in pharynx to regulate MWCNTs toxicity. Furthermore, RSKS-1 regulated MWCNTs toxicity by suppressing the function of AAK-2-DAF-16 signaling cascade. Our results will strengthen our understanding the microRNAs mediated protection mechanisms for animals against the toxicity from certain nanomaterials.
    Title: Function of RSKS-1-AAK-2-DAF-16 signaling cascade in enhancing toxicity of multi-walled carbon nanotubes can be suppressed by mir-259 activation in Caenorhabditis elegans.
  4. Transcription factors CEP-1 and CEH-23 collaborate with AAK-2 to modulate longevity in Caenorhabditis elegans.
    Title: Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans.
  5. he results revealed that RNAi-mediated inactivation of several genes restores gonad elongation, including aak-2, which encodes the catalytic subunit of AMP-activated protein kinase (AMPK). We then generated triple mutant worms for cnnm-1; cnnm-3; aak-2 and confirmed that the aak-2 mutation also suppressed the defective gonadal elongation in cnnm-1; cnnm-3 mutant worms.
    Title: Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.
  6. AAK-2 regulates oxidative metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 transcriptional regulators.
    Title: AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators.
  7. Knockdown of Indy/CeNAC2 increased life span by 22+/-3 % compared to controls, together with a decrease in whole body fat content by ~50%. Indy/CeNAC2 reduction also increased the activation of the intracellular energy sensor AMPK/aak2.
    Title: Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2.
  8. As in elevated serotonin signaling, inactivation of AAK-2 in the ASI neurons caused enhanced secretion of dense core vesicles from these neurons.
    Title: Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions.
  9. AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS
    Title: Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.
  10. An essential output of RSKS-1 in axon regrowth is the metabolic sensor AMP kinase, AAK-2.
    Title: S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-2
NP_001024868.1
  • Confirmed by transcript evidence
NP_510710.2
  • Confirmed by transcript evidence
NP_510711.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16796087..16803398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078310.8 → NP_510711.2  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510711.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95ZQ4
    Conserved Domains (4) summary
    cd12122
    Location:460 → 622
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    smart00220
    Location:87 → 339
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14336
    Location:356 → 417
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:84 → 339
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. NM_078309.7 → NP_510710.2  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510710.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22068, Q86FL6, Q95ZQ4
    Conserved Domains (4) summary
    cd12122
    Location:462 → 624
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    smart00220
    Location:87 → 339
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14336
    Location:356 → 419
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:84 → 339
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  3. NM_001029697.6 → NP_001024868.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95ZQ4
    Conserved Domains (4) summary
    cd12122
    Location:398 → 560
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    smart00220
    Location:25 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14336
    Location:294 → 355
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:22 → 277
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95ZQ4.2

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